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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제28권 제2호
- 발행연도
- 2005.1
- 수록면
- 216 - 219 (4page)
이용수
초록· 키워드
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Wogonin (5,7-dihydroxy-8-methoxyflavone) has been reported to exhibit a variety of biological properties including anti-inflammatory and neuroprotective functions. In this study, biological activities of diverse synthetic wogonin derivatives have been evaluated in two experimental cell culture models. Inhibitory activities of wogonin derivatives on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 microglial cells and on hydrogen peroxide ($H_{2}O_2$)-induced neuronal cell death in SH-SY5Y human neuroblastoma were examined. Wogonin derivatives such as WS2 and WS3 showed more potent suppressive activities on LPS-induced NO production and $H_{2}O_2$-induced cytotoxicity than wogonin itself. In addition, thiol substitution played a minor role in enhancing the activities of the derivatives. These findings may contribute to the development of novel anti-inflammatory and neuroprotective agents derived from wogonin.
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Structure and Antiinflammatory Activity Relationships of Wogonin Derivatives
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
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Neuroprotective Effect of Wogonin： Potential Roles of Inflammatory Cytokines
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
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Structural Alterations of Wogonin Significantly Reduce the Inhibitory Activity against COX-2 Catalyzed PGE Production from LPS-Induced RAW 264.7 Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2009 .01
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Wogonin이 polyinosinic-polycytidylic acid로 유발된 인간 신경모세포종 SH-SY5Y의 hydrogen peroxide 생성증가에 미치는 영향
동의생리병리학회지
2012 .08
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Wogonin이 polyinosinic-polycytidylic acid로 유발된 인간 신경모세포종 SH-SY5Y의 hydrogen peroxide 생성증가에 미치는 영향
동의생리병리학회지
2012 .01
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Wogonin and Its Analogs
대한약학회 학술대회
2003 .01
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[지상 14] Wogonin Suppresses Ethanol-induced caspase-11 expression and cell death in N2a neuroblastoma cells
대한체질인류학회 학술대회 연제 초록
2005 .05
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Suppression of Cyclooxygenase-2 Expression of Skin Fibroblasts by Wogonin, a Plant Flavone from Scutellaria Radix
한국응용약물학회 추계학술발표논문집
2003 .01
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마우스에서 황금 유래 Wogonin의 Th1과 Th2 사이토가인 조절 효과
동의생리병리학회지
2005 .08
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Histopathological Comparison of Animal Models of Skin Inflammation and Inhibition of the Inflammatory Responses by Plant Flavonoid, Wogonin
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2005 .01
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Inhibition of Contact Dermatitis in Animal Models and Suppression of Proinflammatory Gene Expression by Topically Applied Flavonoid, Wogonin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
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Chondroprotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
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Suppression of Cyclooxygenase-2 and inducible Nitric Oxide Synthase Enzyme Induction from Lipopolysaccharide-induced RAW 264.7 by Wogonin, a Plant Flavone from Scutellaria Radix
대한약학회 학술대회
2000 .01
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마우스에서 황금 유래 Wogonin의 Th1과 Th2 사이토가인 조절 효과
동의생리병리학회지
2005 .01
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Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells
Tuberculosis and Respiratory Diseases
2014 .01
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Different Effects of Flavonoids in Scutellaria baicalensis on Anxious and Sedative Behaviors
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2006 .01
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Neuroprotective effect of woganin in a rodent model of permanent focal cerebral ischemia
대한약학회 학술대회
2002 .01
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Wogonin protects neuronal cells from excitotoxic and oxidative injuries in primary cultured rat cortical cells
대한약학회 학술대회
2002 .01
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Neuroprotective effects of baicalein. baicalin. and wogonin in primary cultured rat cortical cells
대한약학회 학술대회
2002 .01
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Wogonin inhibits Cytokine-induced TARC/CCL17 Expression by Suppression of NF-${\kappa}B$ activation via p38 MAP kinase Signalning Pathways in HaCaT Keratinocytes
동의생리병리학회지
2007 .01
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