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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 저널정보
- 한국응용약물학회 한국응용약물학회 추계학술발표논문집 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
- 발행연도
- 2003.1
- 수록면
- 96 - 96 (1page)
이용수
이 논문의 연구 히스토리 (2)
2003
Effects of Wogonin, a Plant Flavone from Scutellaria Radix, on Skin Inflammation:In Vivo Regulation of Inflammation-associated Gene Expression
Chi
,
Yeon-Sook
,
Lim
외 6명
대한약학회 학술대회
2003.01
학술대회자료
Suppression of Cyclooxygenase-2 Expression of Skin Fibroblasts by Wogonin, a Plant Flavone from Scutellaria Radix
Chi
,
Yeon-Sook
,
Kim
외 1명
한국응용약물학회 추계학술발표논문집
2003.01
학술대회자료
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초록· 키워드
오류제보하기
Previously, wogonin (5,7-dihydroxy-8-methoxyflavone) was found to suppress proinflammatory enzyme expression including cyclooxygenase-2 (COX-2), contributing to in vivo anti-inflammatory activity against skin inflammation. However, the detailed effect on each skin cell type has not been understood. Therefore, present investigation was carried out to find the effect of wogonin on inflammation-associated gene expression from skin fibroblasts in culture using reverse transcriptase-polymerase chain reaction. As a result, it was found that wogonin (10 - 100 ${\mu}$M) clearly down-regulated COX -2 expression from NIH/3T3 cells treated with 12-O-tetradecanoylphorbol 13-acetate, interleukin-1${\beta}$ or tumor necrosis factor-a. But, the expression levels of COX-1, interleukin-1${\beta}$ and fibronectin were not significantly affected. This finding was well correlated with significant reduction of prostaglandin E$_2$(PGE$_2$) production by wogonin. As a comparison, NS-398 (selective cyclooxygenase-2 inhibitor) did not suppress COX -2 expression and other gene levels, while PGE$_2$production was potently reduced at 0.1 - 10 ${\mu}$M. All these results suggest that COX -2 down-regulation of skin fibroblasts may be, at least in part, one of anti-inflammatory mechanisms of wogonin against skin inflammation.
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Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix
대한약학회 학술대회
2001 .01
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Structure and Antiinflammatory Activity Relationships of Wogonin Derivatives
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
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Structural Alterations of Wogonin Significantly Reduce the Inhibitory Activity against COX-2 Catalyzed PGE Production from LPS-Induced RAW 264.7 Cells
Biomolecules & Therapeutics(구 응용약물학회지)
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Histopathological Comparison of Animal Models of Skin Inflammation and Inhibition of the Inflammatory Responses by Plant Flavonoid, Wogonin
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2005 .01
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Effects of Wogonin, a Plant Flavone from Scutellaria Radix, on Skin Inflammation:In Vivo Regulation of Inflammation-associated Gene Expression
대한약학회 학술대회
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Inhibition of Contact Dermatitis in Animal Models and Suppression of Proinflammatory Gene Expression by Topically Applied Flavonoid, Wogonin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
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Synthetic Wogonin Derivatives Suppress Lipopolysaccharide-Induced Nitric Oxide Production and Hydrogen Peroxide-Induced Cytotoxicity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
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Neuroprotective Effect of Wogonin： Potential Roles of Inflammatory Cytokines
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
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Suppression of Cyclooxygenase-2 and inducible Nitric Oxide Synthase Enzyme Induction from Lipopolysaccharide-induced RAW 264.7 by Wogonin, a Plant Flavone from Scutellaria Radix
대한약학회 학술대회
2000 .01
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Wogonin and Its Analogs
대한약학회 학술대회
2003 .01
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마우스에서 황금 유래 Wogonin의 Th1과 Th2 사이토가인 조절 효과
동의생리병리학회지
2005 .08
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마우스에서 황금 유래 Wogonin의 Th1과 Th2 사이토가인 조절 효과
동의생리병리학회지
2005 .01
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Chondroprotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
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$CD4^+$ Jurkat T 세포주에서 Th1과 Th2 사이토가인 조절에 미치는 황금 유래 Baicalin, Baicalein 및 Wogonin의 효과
동의생리병리학회지
2005 .01
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Immunosuppressive Activity of Wogonin from Scutellaria Radix on DNFB-induced Delayed Type Hypersensitivity in Mice
대한동의병리학회 학술대회논문집
2005 .08
-
Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells
Tuberculosis and Respiratory Diseases
2014 .01
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[지상 14] Wogonin Suppresses Ethanol-induced caspase-11 expression and cell death in N2a neuroblastoma cells
대한체질인류학회 학술대회 연제 초록
2005 .05
-
Different Effects of Flavonoids in Scutellaria baicalensis on Anxious and Sedative Behaviors
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2006 .01
-
Neuroprotective effect of woganin in a rodent model of permanent focal cerebral ischemia
대한약학회 학술대회
2002 .01
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Wogonin이 polyinosinic-polycytidylic acid로 유발된 인간 신경모세포종 SH-SY5Y의 hydrogen peroxide 생성증가에 미치는 영향
동의생리병리학회지
2012 .01
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