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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국광과학회 Journal of photoscience : an international journal officail organ of the korean society of photoscience Journal of photoscience : an international journal officail organ of the korean society of photoscience 제9권 제2호
- 발행연도
- 2002.1
- 수록면
- 433 - 435 (3page)
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이 논문의 연구 히스토리 (2)
2002
Sphingosine-1-phosphate Promotes the Survival of Mel-Ab Cells via ERK and Akt activation
Kim
,
Dong-Seok
,
Hwang
외 8명
Journal of photoscience : an international journal officail organ of the korean society of photoscience
2002.01
학술저널
Sphingosine-1-phosphate Promotes the Survival of Mel-Ab Cells via ERK and Akt activation
Kim
,
Dong-Seok
,
Hwang
외 10명
대한약학회 학술대회
2002.01
학술대회자료
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In the present study, we investigated the actions of sphingosine-I-phosphate (SPP) in Mel-Ab melanocytes. We observed the cytoprotective effect of SPP on UVB-induced cell death. Following exposure of cells to UVB, a significant protective effect was seen in cultures pretreated with SPP. Since SPP is well known as a mitogenic agent, it is possible that the mitogenic effect of SPP may contribute to cell survival. Surprisingly, we found that SPP inhibited DNA-synthesis significantly. We were next interested in the regulation of the extracellular signal-regulated protein kinase (ERK) and Akt pathways by SPP. We clearly observed that SPP potently stimulated the phosphorylation of both ERK and Akt against UVB-induced cell death. Based on these results, we conclude that SPP may show its cytoprotective effect through ERK and Akt activation.
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