지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 20 (20page)
이용수
초록· 키워드
오류제보하기
Radiotherapy is a frequent mode of cancer treatment, although the development of radioresistance limits its effectiveness. Extensive investigations indicate the diversity of the mechanisms underlying radioresistance. Here, we aimed to explore the effects of extracellular signal-regulated kinase 5 (ERK5) on lung cancer radioresistance and the associated mechanisms. Our data showed that ERK5 is activated during solid lung cancer development, and ectopic expression of ERK5 promoted cell proliferation and G2/M cell cycle transition. In addition, we found that ERK5 is a potential regulator of radiosensitivity in lung cancer cells. Mechanistic investigations revealed that ERK5 could trigger IR-induced activation of Chk1, which has been implicated in DNA repair and cell cycle arrest in response to DNA double-strand breaks (DSBs). Subsequently, ERK5 knockdown or pharmacological inhibition selectively inhibited colony formation of lung cancer cells and enhanced IR-induced G2/M arrest and apoptosis. In vivo, ERK5 knockdown strongly radiosensitized A549 and LLC tumor xenografts to inhibition, with a higher apoptotic response and reduced tumor neovascularization. Taken together, our data indicate that ERK5 is a novel potential target for the treatment of lung cancer, and its expression might be used as a biomarker to predict radiosensitivity in NSCLC patients.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Biphasic activation of extracellular signal-regulated kinase (ERK) 1/2 in epidermal growth factor (EGF)-stimulated SW480 colorectal cancer cells
BMB Reports
2016 .01
-
FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cells
Experimental and Molecular Medicine
2022 .01
-
Downregulated CDK10 promotes cancer progression and radioresistance in lung cancer through activating the JNK/c-Jun signaling pathway
BMB Reports
2024 .07
-
Isoproterenol increases histone deacetylase 6 expression and cell migration by inhibiting ERKsignaling via PKA and Epac pathways in human lung cancer Cells
Experimental and Molecular Medicine
2016 .01
-
Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications
Experimental and Molecular Medicine
2023 .06
-
The study on survivability of Korean-American Lung cancer patients in SEER data with Kaplan Meier Method
대한인간공학회 학술대회논문집
2015 .10
-
Apoptosis inhibitor 5 increases metastasis via Erk-mediated MMP expression
BMB Reports
2015 .01
-
Novel discrimination system for lung cancer cell with virus based color structure
한국고분자학회 학술대회 연구논문 초록집
2015 .04
-
GPR78 promotes lung cancer cell migration and metastasis by activation of Gq-Rho GTPase pathway
BMB Reports
2016 .01
-
비소세포 폐암 병기 예측을 위한 전이 학습 및 임상 변수 활용
대한전자공학회 학술대회
2021 .06
-
Tumor microenvironment and radioresistance
Experimental and Molecular Medicine
2021 .06
-
Phospholipid dynamics in ex vivo lung cancer and normal lung explants
Experimental and Molecular Medicine
2021 .01
-
딥러닝을 활용한 멀티모달 CT의 2D 조인트 히스토그램 기반 폐암 종류 분류
대한전자공학회 학술대회
2018 .06
-
Extraction of Lung Tumor Regions from Thoracic CT Images Using An Improved U-Net
제어로봇시스템학회 국제학술대회 논문집
2023 .10
-
DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities
Experimental and Molecular Medicine
2022 .10
-
In Vitro Three-dimensional Vascularized Lung Cancer-on-a-chip Using Decellularized Lung Extracellular Matrix Hydrogel
한국고분자학회 학술대회 연구논문 초록집
2019 .10
-
In Vitro Three-dimensional Vascularized Lung Cancer-on-a-chip Using Decellularized Lung Extracellular Matrix Hydrogel
한국고분자학회 학술대회 연구논문 초록집
2019 .04
-
High expression of RAD51 promotes DNA damage repair and survival in KRAS-mutant lung cancer cells
BMB Reports
2019 .01
-
P42 Ebp1 functions as a tumor suppressor in non-small cell lung cancer
BMB Reports
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0