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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 420 - 427 (8page)
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초록· 키워드
오류제보하기
FTY720, a synthetic sphingoid base analog, was
examined as a new sphingosine kinase inhibitor,
which converts endogenous sphingosine into its
phosphate form. W ith 20 μM of FTY720, sphingosine
accumulated in the LLC-PK1 cells in a
time- and dose-dependent manner. The FTY720
treated cells showed a high concentration of
fragmented DNA, a high caspase-3 like activity
and TUNEL staining cells. It was also found that
the sphingosine and sphinganine level increased
in a time- and dose-dependent manner within 12
h after the FTY720 treatment. The sphingosine
kinase activity was reduced by FTY720 as much
as other sphingosine kinase inhibitors, N, N-dimethylsphingosine
(DMS), dl-threo-dihydrosphingosine
(DHS). The fragmented DNA content as
a result of the 20 μM of FTY720 treatment and
by 5 μM of the exogenously added BSA-sphingosine
complex indicated typical apoptosis. Under
similar conditions, the accumulated sphingosine
concentration in all the cells was almost
identical even though the sphingosine distribution
inside the cells was somewhat different.
These results indicate that the FTY720 induced
apoptosis is associated with the inhibition of the
sphingosine kinase activity and is strongly associated
with the successive accumulation of
sphingosine.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
/ / A possible role of sphingosine in inductionof apoptosis by tumor necrosis factor-alpha in human neutrophils : 267 ~ 70
/ / Quantitation of free sphingosine in liver by highperformanceliquid chromatography : 373 ~ 81
/ 1995 / Induction of apoptosis by sphingosine inhuman leukemic HL-60 cells a possible endogenous modulatorof apoptotic DNA fragmentation occurring during phorbolester-induc
/ 1995 / Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant : 396 ~ 403
/ 1995 / an alternative mechanism for generatingdeath signals : 405 ~ 11
/ / Quantitation of free sphingosine in liver by highperformanceliquid chromatography : 373 ~ 81
/ 1995 / Induction of apoptosis by sphingosine inhuman leukemic HL-60 cells a possible endogenous modulatorof apoptotic DNA fragmentation occurring during phorbolester-induc
/ 1995 / Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant : 396 ~ 403
/ 1995 / an alternative mechanism for generatingdeath signals : 405 ~ 11
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