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논문 기본 정보

자료유형
학술저널
저자정보
Koh, Sang-Baek (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University) Park, Jun-Ho (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University) Yun, Ju-Song (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University) Lee, Kang-Myoung (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University) Cha, Bong-Suk (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University) Chang, Sei-Jin (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University) Kim, Cheong-Sik (Department of Preventive Medicine, Seoul National University College of Medicine) Kim, Heon (Department of Preventive Medicine, College of Medicine, Chungbuk National University) Chang, Soung-Hoon (Department of Preventive Medicine, College of Medicine, Kunkuk University)
저널정보
대한독성유전단백체학회 Molecular & cellular toxicology Molecular & cellular toxicology 제2권 제2호
발행연도
2006.1
수록면
134 - 140 (7page)

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Because shipyard workers are involved with various manufacturing process in shipyard industry, and they are exposed to many kinds of hazardous materials. Especially, painting workers were exposed polycyclic aromatic hydrocarbons (PAH). This study was conducted to assess the exposure status of PAH based on job-exposure matrix. We investigated the effect of genetic polymorphism of xenobiotic metabolism enzymes involved in PAH metabolism on levels of urinary metabolite. A total of 93 shipbuilding workers were recruited in this study. Questionnaire variables were age, sex, use of personal protective equipment, smoking, drinking, and work duration. The urinary metabolite was collected in the afternoon and corrected by urinary creatinine concentration. The genotypes of CYP1A1, CYP2E1, GSTM1, GSTT1 and UGT1A6 were investigated by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods with DNA extracted from venous blood. Urinary 1-OHP levels were significantly higher in direct exposured group (spray and touch-up) than indirect exposed group. Urinary 1-OHP, concentration of the high exposure with wild type of UGT1A6 was significantlyhigher than that of the high exposure with other UGT1A6 genotype. In multiple regression analysis of urinary 1-OHP, the regression coefficient of job grade was statistically significant (p<0.05) and UGT1A6 was not significant but a trend (p<0.1). The grade of exposure affected urinary PAH concentration was statistically significant. But genetic polymorphism of xenobiotics metabolism enzymes was not statistically significant. Further investigation of genetic polymorphism with large sample size is needed.
#Polycyclic aromatic hydrocarbons #Genetic polymorphism #1-hydroxypyren

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