다환성 방향족 탄화수소 노출에 의한 DNA 산화적 손상과 paraoxonase-1 (PON1) 유전자 다형성이 폐암 발생에 미치는 영향

이철호; 이계영; 최강현; 홍윤철; 김용대; 강종원; 김헌

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자료유형: 학술저널

저자정보: 이철호 이계영 최강현 홍윤철 김용대 강종원 김헌

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제38권 제3호

발행연도: 2005.1

수록면: 345 - 350 (6page)

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Objectives : Polycyclic aromatic hydrocarbons (PAHs), which are risk factors for lung cancer, have been reported to induce oxidative DNA damage. The paraoxonase (PON) plays a significant role in the detoxification of a variety of organophosphorous compounds, with paraoxonase-1 (PON1) being one of the endogenous free-radical scavenging systems in the human body. The aim of this case-control study was to investigate the effects of PAH exposure, oxidative stress and the Q192R polymorphism of PON1 genes, and their interactions in the carcinogenesis of lung cancer. Methods : One hundred and seventy seven lung cancer patients and 177 age- and sex-matched controls were enrolled in this study. Each subject was asked to complete a questionnaire concerning their smoking habits and environmental exposure to PAHs. The Q192R genotypes of the PON1 gene was examined, and the concentrations of urinary 1-hydroxypyrene (1-OHP), 2-naphthol and 8- hydroxydeoxyguanosine (8-OH-dG) measured. Results : Cigarette smoking was found to be a significant risk factor for lung cancer. The urinary 8-OH-dG level was higher in the patients, whereas the urinary 1-OHP and 2- naphthol levels were higher in the controls. There was a significant correlation between the urinary levels of 8-OHdG and 1-OHP in both the cases and controls. The PON1 polymorphism was associated with an increased risk of lung cancer. Individuals carrying the Q/Q genotype of the PON1 gene were found to be at higher risk of developing lung cancer. There was a significant correlation between the urinary levels of 8-OH-dG and 1-OHP in those with the PON1 Q/Q genotype. Conclusions : These results lead to the conclusion that PAHs would induce oxidative DNA damage, especially in individuals with the PON1 Q/Q genotype. Therefore, people with the PON1 Q/Q genotype would be more susceptible to lung cancer than those with the R/R or Q/R genotypes of the PON1 gene.

#Lung cancer #Paraoxonase-1 #8-hydroxydeoxyguanosine #Polycyclic aromatic hydrocarbons

참고문헌 (27)

참고문헌 신청

American Cancer Society / 2001 / Tobacco use. In:American Cancer Society(Ed). Cancer facts& figures : 29 ~ 32

Aynacioglu AS / 1999 / Paraoxonase1 mutations in a Turkish population 157 : 174 ~ 177

De Stefani E / 1993 / The effect of alcohol on therisk of lung cancer in Uruguay 2 : 21 ~ 26

Dizdaroglu M / 1992 / Oxidative damage to DNA inmammalian chromatin 275 : 331 ~ 342

Dosemeci M / 1997 / Tobacco,alcohol use,and risks oflaryngeal and lung cancer by subsite andhistologic type in Turkey 8 : 729 ~ 737

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