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논문 기본 정보

자료유형
학술저널
저자정보
Zakir Hossain, S.M. (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) Golam Azam, S.M. (Room No, 16, Old PG Doctor's Hostel, Dhaka Medical College Hospital) Enayetul Babar, S.M. (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
저널정보
대한독성유전단백체학회 Molecular & cellular toxicology Molecular & cellular toxicology 제2권 제1호
발행연도
2006.1
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1 - 6 (6page)

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Photodynamic therapy (PDT), a newly established treatment for solid tumors, involves the systemic administration of a tumor localizing photosensitizer that is only activated when exposed to light of appropriate wavelength. Photoactivation of photosensitizer in the presence of oxygen results in the formation of highly cytotoxic molecular species, which precipitates necrosis. PDT has now become a promising means for the treatment of cancer due to its specificity, relatively minimal side effects, and inexpensive. However, the application of PDT has been restricted to the treatment of superficial lesions or the use of interstitial light delivery. A single photon generally activates the photochemical reaction in traditional PDT. However the use of multi photon excitation, where two or more photons simultaneously excite a photosensitizer, allows for the use of wavelengths twice as long. Such wavelengths exhibit better transmittance through tissue and thereby deeper penetration is achieved. This paper will review theoretical principles of multi photon excitation, challenges associated with multi photon PDT and update the current and future role of multi photon PDT in cancer.

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