지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 23 - 32 (10page)
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Background: Although photodynamic therapy (PDT) is widely performed for acne, little is known about its exact therapeutic mechanism. Objective: We aimed to estimate the efficacy and safety of PDT on acne and to discover its mode of action. Methods: We performed PDT on 12 patients with mild to moderate acne. The clinical efficacy was assessed by counting the acne lesions and measuring the sebum secretion before and after PDT. In addition, we took biopsy samples from the peri-lesional areas before and after 3-session of PDT. To examine the degree of apoptosis of the sebaceous follicles, TUNEL assay was performed. To investigate the changes of toll-like receptor (TLR)-2 and TLR-4 expression after PDT, immunohistochemical stainings were also carried out. Finally, we performed TUNEL assay using the cultured sebocytes to confirm the apoptosis of sebocytes in vitro after PDT. Results: There was a significant reduction in the number of inflammatory acne lesions after PDT, compared to baseline (p＜0.05). Sebum excretion significantly decreased 2 weeks after the first PDT session except for one patient (p＜0.05). The TUNEL positive cells in the peri-lesional sebaceous glands after PDT markedly increased, compared with those of before PDT. A decrease in TLR-2 and TLR-4 expression by sebaceous glands and epidermis after PDT was 50% and 30%, respectively.
Conclusion: Our results demonstrate that apoptosis of the sebaceous glands is associated with improvement of acne by PDT. PDT has shown to down-regulate TLR-2 and TLR-4expression in the sebaceous glands and epidermis of acne patients. (Ann Dermatol 23(1) 23∼32, 2011)
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참고문헌 (24)
참고문헌 신청
Aderem A / 2000 / Toll-like receptors in the induction of the innate immune response / Nature 406 : 782 ~ 787
Ashkenazi H / 2003 / Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light / FEMS Immunol Med Microbiol 35 : 1
Baker BS / 2003 / Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis / Br J Dermatol 148 : 670 ~ 67
Bednarz N / 2007 / Protoporphyrin IX induces apoptosis in HeLa cells prior to photodynamic treatment / Pharmacol Rep 59 : 474 ~ 479
Divaris DX / 1990 / Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protopor
Ashkenazi H / 2003 / Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light / FEMS Immunol Med Microbiol 35 : 1
Baker BS / 2003 / Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis / Br J Dermatol 148 : 670 ~ 67
Bednarz N / 2007 / Protoporphyrin IX induces apoptosis in HeLa cells prior to photodynamic treatment / Pharmacol Rep 59 : 474 ~ 479
Divaris DX / 1990 / Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protopor
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