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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 112 - 119 (8page)
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ObjectiveThis study aimed to evaluate the potential effects of cisplatin on photodynamic therapy (PDT) in breast cancer using abreast tumor-bearing mouse model. MethodsIn this study, breast tumor (experimental mammary tumour-6 cell)-bearing nude mice were used as experimentalanimals. Photolon® (photosensitizer, 2.5 mg/kg body weight [BW]) was injected intraperitoneally; after 2 hours,the tumors were irradiated (660 nm, 80 J/cm2) using a diode laser tool. Cisplatin (3 mg/kg BW) was injectedintraperitoneally 1 hour before the Photolon® injection. ResultsTumor volume increased over time in the control group and was not different from that in the cisplatin group. Inthe PDT group, the tumor volume increased on day 3, but not on day 7. In the cisplatin+PDT group, tumor volumeincreased on day 3 but decreased on day 7. There was no significant difference in the levels of thiobarbituric acidreactive substance (TBARS) in tumor tissues between the control and cisplatin groups. The levels of TBARS in thecisplatin+PDT group were higher (47%) than those in the PDT group. Analysis of tumor tissue transcriptomes showedthat the expression of genes related to the inflammatory response including CL and XCL genes increased, while thatof Fn1 decreased in the cisplatin+PDT group compared with the PDT group. ConclusionThese results suggest that cisplatin enhances the therapeutic effect of PDT in a breast tumor-bearing mouse model. However, further clinical studies involving patients with breast cancer is needed.
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참고문헌 (32)
참고문헌 신청
McGuire A / 2015 / Effects of age on the detection and management of breast cancer / Cancers(Basel) 7:908~929
Mangla B / 2018 / Combination of natural agent with synthetic drug for the breast cancer therapy / Int J Drug Dev Res 10:22~26
Agostinis P / 2011 / Photodynamic therapy of cancer : an update / CA Cancer J Clin 61:250~281
Silva JN / 2006 / Photodynamic therapies : principles and present medical applications / Biomed Mater Eng 16:S147~54
O’Connor AE / 2009 / Porphyrin and nonporphyrin photosensitizers in oncology : preclinical and clinical advances in photodynamic therapy / Photochem Photobiol 85:1053~1074
Mangla B / 2018 / Combination of natural agent with synthetic drug for the breast cancer therapy / Int J Drug Dev Res 10:22~26
Agostinis P / 2011 / Photodynamic therapy of cancer : an update / CA Cancer J Clin 61:250~281
Silva JN / 2006 / Photodynamic therapies : principles and present medical applications / Biomed Mater Eng 16:S147~54
O’Connor AE / 2009 / Porphyrin and nonporphyrin photosensitizers in oncology : preclinical and clinical advances in photodynamic therapy / Photochem Photobiol 85:1053~1074
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