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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제4호
발행연도
2006.1
수록면
468 - 471 (4page)

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Photodynamic therapy (PDT) is a method used to treat cancer early by irradiating laser with suitable wavelength after injection of a photosensitizer. We introduce the result of PDT for treating an early glottic cancer where initial treatment modality had failed. We tried PDT for 2 patients:one had recurrence after laser cordectomy (T1b) and the other after radiation therapy (T2). Photogem 2 mg/kg was injected intravenously and laser irradiation was performed after 48 hours. We irradiated the lesion site using diode laser (630 nm) delivered through 5 mm cylindrical fiber tip. The energy density, as determined by the depth and site of the lesion, were 138 J/cm and 204 J/cm, respectively. Patient with T1b is alive with no evidence of disease for 46 months post- PDT follow up. Patient with T2 developed chondritis at the subglottis but improved after hyperbaric oxygen therapy and several surgical debridement. After 4 months, tumor recurred at both vocal folds and was managed with total laryngectomy. PDT is a new treatment modality with advantages of good voice quality, short period of admission, and less rate of morbidity and may be another useful salvage option. (Korean J Otolaryngol 2006;49:468-71)

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