지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
A cepfialosporin with an aminothiazoiylmethoxyimino-type side chain at the 7 position and bicyclic quinolone dithicarbamate at the 3' position was synthesized. It has broad and potent antivacterial activity in vitro. The antibacterial spectrum reflects contributions of both the cephalosporin moiety and the quinolone moiety. Thus, this compound was named DACD implying a dualaction cephalosporin derivative. In this paper, the physicochemical proper-ties (lipid-water partition, pKa), stability and pharmacokinetics of DACD were determined and compared with cefotaxime 3'-norfloxacin dithiocarbamate (CENO). Stability tests were studied in pH 1.20, 6.80 and 8.00 buffers and in the presence of AB type human plasma, rat liver homogenate and its .betha.-lactamase. The pharmacokinetic parameters of DACD were evaluated in mice after a single intravenous dose of 40 mg/kg. The results are as follows. The lipid-water partition coefficient of DACD was higher than that of CENO. The calculated pKa values of CENO and DACD, were 6.82$\pm$0.03, 7.53$\pm$0.21, respectively. In the hydrolysis test, half-lives (t$^{1/2}$) of CENO and DACD was 66.0 hr and 80.0 hr in pH 6.80 buffer, 190 hr and 91.4 hr in pH 8.00 buffer. CENO and DACD were rapidly hydrolyzed in human plasma and in rat liver hornogenate. Half-lives (t$_{1/2}$ of CENO and DACD were 1.29 hr and 1.15 hr in hyman plasma, 0.62 hr and 0.71 hr rat liver homogenate. In $\beta$-lactamase stability test, CENO and DACD were very stable to the .betha.-lactamases obtained from three different strains. Half-life (t$_{1/2}$) and areas under the curve (AUC) in mice were 2.33 hr and 15.97 (mg.h/1), respectively.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
새로운 경구용 세팔로스포린류의 물리화학적 성질 및 분해특성
약학회지
1994 .01
-
High Performance Liquid Chromatographic Analysis of Rabeprazole in Human Plasma and its Pharmacokinetic Application
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
가토에서의 Praziquantel의 체내 동태
약학회지
1990 .01
-
Clinical Significance of Pharmacokinetic Evaluation
대한임상약리학회 심포지움
1993 .01
-
Pharmacokinetics after Gastrectomy
대한외과학회 학술대회 초록집
2019 .10
-
Downregulated MicroRNA-133a in Gastric Juice as a Clinicopathological Biomarker for Gastric Cancer Screening
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Development of physiological pharmacokinetic model
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1987 .01
-
항류마치스 효과를 갖는 새로운 히스톤 H1 단백질 (p961)의 흰쥐와 토끼에 대한 약물동태
약학회지
2001 .01
-
신규 퀴놀론계 항생물질 DWQ-013의 흰쥐 및 생쥐에서의 체내동태
약학회지
1995 .01
-
생약제제의 약물동태 연구 및 상호작용
한국임상약학회지
2010 .01
-
HPLC Analysis, Stability, Blood Partition, Protein Binding, and Dose-independent Pharmacokinetics of A New Reversible Proton Pump Inhibitor, KR-60436, after Intravenous and Oral Administration to Rats
대한약학회 학술대회
2001 .01
-
인터루킨-2의 제제설계를 위한 체내 동태학적 연구
약학회지
1990 .01
-
Pharmacokinetic Assessment in Early Phase Clinical Trials : Design and Data Analysis
대한임상약리학회 심포지움
1993 .01
-
클라리스로마이신의 건강한 한국 성인에 대한 집단 약물동태
약학회지
2002 .01
-
항생제 Fluoroquinolones의 약동학 및 약력학에 관한 최신 정보
Urogenital Tract Infection
2015 .01
-
Proposed Stability Guideline - Evaluation and Statistical Analysis of Stability Data
대한약학회 학술대회
2004 .01
-
신규 세파로스포린계 항생물질 DWC-751의 흰쥐 및 생쥐 체내동태
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1993 .01
-
토끼에서 체내담즙이 아세부톨롤의 생체이용률 및 체내동태에 미치는 영향
약학회지
2002 .01
-
신규 캄토테신계 항암제 CKD-602의 약물동태: 흡수
약학회지
1998 .01
-
새로운 11β-HSD1 저해제인 KR-67500의 약물동태
약학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0