지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The pharmacokinetics of CKD-602, a new camptothecin anticancer derivative, were studied in mice, rats and dogs following a single or multiple intravenous administration, and the following results were obtained. The blood levels of CKD-602 declined in biphasic fashions with peak plasma levels $(C_0)$ of $2.63{\mu}g/ml$ in mice, $2.27{\mu}g/ml$ in tumor bearing mice, $2.84{\mu}g/ml$ in rats at a dose of 20mg/kg, and of 0.02mcg/ml in dogs at a dose of 0.5mg/kg. The plasma half-lives $(t_{1/2}{\beta})$ were 9.55hr in mice, 9.94hr in tumor bearing mice, 9.98hr in rats and 12.75hr in dogs. AUC of CKD-602 was increased linearly with the dose at a range from 5 to 20mg/kg. Moreover, Cltot and Vdss were also not significantly changed with increasing the dose. On the other hand, after 5 daily intravenous bolus injection of CKD-602 (5mg/kg) in rats, $t_{1/2}{\beta}$, AUC and MRT of CKD-602 were 11.90hr, $3.19{\mu}g{\cdot}hr/ml$, and 11.61hr, respectively, which were slightly higher than after the single bolus injection.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
신규 캄토테신계 항암제 CKD-602의 약물동태: 분포, 대사 및 배설
약학회지
1998 .01
-
Comparison of Single-Dose Toxicity by Intravenous Infusion or Bolus Injection with CKD-602, a Camptothecin Anticancer Agent in Rats (II): Hematological and Serum Biochemical, and Histopathological Changes
Toxicological Research
2004 .12
-
Comparison of Single-Dose Toxicity by Intravenous Infusion or Bolus Injection with CKD-602, a Camptothecin Anticancer Agent in Rats (I): Toxic Effects with regard to Mortality and Clinical Signs
Toxicological Research
2004 .12
-
Absorption, Distribution, Metabolism, and Excretion of CKD-732, a Novel Antiangiogenic Fumagillin Derivative, in Rats, Mice, and Dogs
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
In Vitro Pharmacodynamics of CKD-602 in HT-29 Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
Camptothecin계 항암제 CKD-602의 유전독성평가 ( Genotoxicity Studies of An Anticancer Agent of Camptothecin Series, CKD-602 )
한국환경성돌연변이·발암원학회지
1998 .09
-
Development of CKD-602, a novel camptothecin derivative, for anticancer agent
대한약학회 학술대회
2000 .01
-
구강암 세포주에 대한 CKD-602의 항암 효과
대한구강악안면외과학회지
2005 .01
-
Association of Demographic and Socioeconomic Factors With Risk Factors for Chronic Kidney Disease
예방의학회지
2015 .01
-
Higher Risk for All-cause Mortality of Staphylococcus aureus Bacteremia in Patients with Non-Dialysis Dependent Chronic Kidney Disease
Infection and Chemotherapy
2020 .01
-
Acute Toxicity of CKD-602, a New Anticancer Agent, in Rats
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2004 .01
-
Effect of Uric Acid on the Development of Chronic Kidney Disease: The Korean Multi-Rural Communities Cohort Study
예방의학회지
2018 .01
-
CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling
Immune Network
2011 .12
-
Identification of urinary metabolite(s) of CKD-712 by gas chromatography/mass spectrometry in rats
대한약학회 학술대회
2003 .01
-
Toxicity Study of CKD-602, a Camptothecin Anticancer Agent: 5-Day Repeated Intravenous Administration in Rats
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2004 .01
-
Phase I Study of CKD-516, a Novel Vascular Disrupting Agent, in Patients with Advanced Solid Tumors
Cancer Research and Treatment
2016 .01
-
Effect of chronic kidney disease on outcomes of total joint arthroplasty: a meta-analysis
Knee Surgery and Related Research
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0