지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The purpose of this study was to estimate the population pharmacokinetics of clarithromycin in healthy adult Korean and to investigate the factors influencing the pharmacokinetics of clarithromycin. The population pharmacokinetic parameters of clarithromycin were calculated with the data from healthy adult Koreans. A total of 798 plasma concentrations obtained from 78 subjects after administration of a single oral dose of 250 mg or 500 mg were used for the modeling. The concentration-time data were fitted to a one-compartment open model assuming a first-order absorption and elimination with no lag time. The correlations between various factors [such as sex, age, height, weight, sect creatinine (Scr) and dose and pharmacokinetic parameters were estimated with stepwise linear recession analyses. The selected covariates were incorporated in the population model of NONMEM, and the importance of each covariate was investigated by means of backwards elimination. The apparent clearance (CL/F) was significantly correlated to Scr and sex, and the apparent volume of distribution (Vd/F) was significantly correlated to Scr and height in a nonlinear relationship. The population values of Ka was 1.8 h $r_{-1}$, CL/F was 37.71 L/hr, Vd/F was 200 L and t/ sub 1/2 / was 3.68 hrs for a male Korean with 170 m height and 1.0 mg/dL Scr.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Population pharmacokinetics of clarithromycin in healthy adult Korean
대한약학회 학술대회
2001 .01
-
POPULATION PHARMACOKINETICS OF TERBINAFINE IN HEALTHY MALE KOREAN SUBJECTS USING NONMEM
대한약학회 학술대회
2002 .01
-
High Performance Liquid Chromatographic Analysis of Rabeprazole in Human Plasma and its Pharmacokinetic Application
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
건강한 한국인 자원자에서 바데나필 단회 투여 후 내약성 및 약동학적 특성에 관한 연구
임상약리학회지
2012 .01
-
Clinical Significance of Pharmacokinetic Evaluation
대한임상약리학회 심포지움
1993 .01
-
Influence of Clarithromycin on the Pharmacokinetics/Pharmacodynamics of Lansoprazole in Relation to S-mephenytoin Oxidation Polymorphism
대한임상약리학회 학술대회
1998 .01
-
Population pharmacokinetics of aceclofenac in Korean healthy subjects using NONMEM
대한약학회 학술대회
2001 .01
-
소아 Helicobacter pylori 감염에서 Clarithromycin 내성과 연관된 23S rRNA의 돌연변이
Pediatric Gastroenterology, Hepatology & Nutrition
2004 .01
-
Pharmacokinetics after Gastrectomy
대한외과학회 학술대회 초록집
2019 .10
-
Formulation and Evaluation of Less-Painful Clarithromycin Lipid Microspheres
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Development of physiological pharmacokinetic model
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1987 .01
-
Population Analysis of Densely Sampled Pharmacokinetic Data
대한임상약리학회 학술대회
2006 .01
-
한국인의 만성 기관지염의 급성 악화 환자를 대상으로 한 Moxifloxacin 400mg 1 일 1회 요법과 Clarithromycin 500mg 1일 2회 요법의 치료효과 및 안전성 비교
Tuberculosis and Respiratory Diseases
2000 .01
-
반코마이신의 약물동태학적 모델링과 시뮬레이션의 향상을 위한 분석오차
약학회지
2013 .01
-
Population Pharmacokinetic Study of Carbamazepine in Korean
대한임상약리학회 학술대회
1994 .01
-
Population Pharmacokinetic Characteristics of Levosulpiride and Terbinafine in Healthy Male Korean Volunteers
대한약학회 학술대회
2003 .01
-
Pharmacokinetic Assessment in Early Phase Clinical Trials : Design and Data Analysis
대한임상약리학회 심포지움
1993 .01
-
Population Pharmacokinetics of Fluoxetine
대한약학회 학술대회
2001 .01
-
클래리스로마애신 정제의 생물학적 동등성 평가
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1998 .01
-
Pharmacokinetics of Hm30181A, a Novel P-gp Inhibitor, after Single Oral Administration in Healthy Male Subjects
대한임상약리학회 학술대회
2007 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0