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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제42권 제2호
- 발행연도
- 2008.1
- 수록면
- 94 - 99 (6page)
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Background : It has recently been clarified that epidermal growth factor receptor (EGFR),
which is a receptor tyrosine kinase of the erbB family, is abnormally activated in non-small
cell lung carcinomas (NSCLC) and this fact is being utilized for creating targeted therapy. In
this study, we aimed to identify the frequency of the EGFR expression and gene mutation in
NSCLC, and to determine the correlation between them. Methods : Immunohistochemical
staining for EGFR, C-erbB-2, cytokeratin 7, p53 and thyroid transcription factor-1, and EGFR
mutation analysis were performed using paraffin-embedded archival tissue from 228 cases of
NSCLC; this included 112 squamous cell carcinomas and 116 adenocarcinomas. Results :
An EGFR expression and gene mutation occurred in 112 casees (53.5%) and 52 cases (22.8
%), respectively. EGRF mutation was more frequent in the adenocarcinomas than in the squamous
cell carcinomas, in non-smokers than in smokers, and in females than in males. EGFR
mutation was significantly associated with an EGFR protein expression, and especially in adenocarcinomas.
Conclusion : The EGFR expression in NSCLC was associated with EGFR
mutation, and especially in adenocarcinomas. More studies are needed to prove the clinical
significance of the EGFR expression for creating targeted therapy to treat NSCLC.
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참고문헌 (24)
참고문헌 신청
Bejarano PA / 1996 / Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas / Mod Pathol 9 : 445 ~ 452
Cohen S / 1982 / A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles / J Biol Chem 257 : 1523 ~ 1531
Fernandez Val JF / 2002 / Cell proliferation, nuclear ploidy, and EGFR and HER2/neu tyrosine kinase oncoproteins in infiltrating ductal breast carcinoma / Cancer Genet Cytoge
Franklin WA / 2002 / Epidermal growth factor receptor family in lung cancer and premalignancy / Semin Oncol 29 : 3 ~ 14
Gehring WJ / 1987 / Homeo boxes in the study of development / Science 236 : 124 ~ 152
Cohen S / 1982 / A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles / J Biol Chem 257 : 1523 ~ 1531
Fernandez Val JF / 2002 / Cell proliferation, nuclear ploidy, and EGFR and HER2/neu tyrosine kinase oncoproteins in infiltrating ductal breast carcinoma / Cancer Genet Cytoge
Franklin WA / 2002 / Epidermal growth factor receptor family in lung cancer and premalignancy / Semin Oncol 29 : 3 ~ 14
Gehring WJ / 1987 / Homeo boxes in the study of development / Science 236 : 124 ~ 152
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