지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 245 - 253 (9page)
- DOI
- 10.7783/KJMCS.2020.28.4.245
이용수
초록· 키워드
오류제보하기
Background: Research on hot water extracts of medicinal plants that are easily applicable in the clinical setting is essential. To confirm the anti-inflammatory-related active compounds present in the hot water extract of Eriobotrya japonica leaves, ability to inhibit nitric oxide (NO) production was measured and active compounds isolated from the extract were analyzed.
Methods and Results: Sovent fractionation by solvent was performed to identify the active compounds present in the hot water extract, and the ability of the extract and the fractions obtained to inhibit NO production was measured. Subsequently, based on the results of liquid chromatography (LC) profile analysis of the n-butanol fraction that had a relatively high inhibitory ability of NO production, six subfractions were separated around the main peak. Among the separated subfractions spectra from mass spectroscopy (MS) were analyzed and standard comparisons were performed on the compounds of the three main peaks on the chromatogram. NO production inhibitory activity of subfraction 2 identified as neochlorogenic acid was the highest with an IC<SUB>50</SUB> of 18.49 ㎍/㎖ followed by that of subfraction 5 identified as cryptochlorogenic acid with IC<SUB>50</SUB> of 25.82 ㎍/㎖.
Conclusions: Our result, it was confirmed that several caffeoylquinic acids, including neochlorogenic acid and cryptochlorogenic acid present in the hot water extract of E. japonica leaves have an important role as compounds exhibiting anti-inflammatory activity.
Methods and Results: Sovent fractionation by solvent was performed to identify the active compounds present in the hot water extract, and the ability of the extract and the fractions obtained to inhibit NO production was measured. Subsequently, based on the results of liquid chromatography (LC) profile analysis of the n-butanol fraction that had a relatively high inhibitory ability of NO production, six subfractions were separated around the main peak. Among the separated subfractions spectra from mass spectroscopy (MS) were analyzed and standard comparisons were performed on the compounds of the three main peaks on the chromatogram. NO production inhibitory activity of subfraction 2 identified as neochlorogenic acid was the highest with an IC<SUB>50</SUB> of 18.49 ㎍/㎖ followed by that of subfraction 5 identified as cryptochlorogenic acid with IC<SUB>50</SUB> of 25.82 ㎍/㎖.
Conclusions: Our result, it was confirmed that several caffeoylquinic acids, including neochlorogenic acid and cryptochlorogenic acid present in the hot water extract of E. japonica leaves have an important role as compounds exhibiting anti-inflammatory activity.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (24)
참고문헌 신청
배영일 / 2002 / 비파 부위별 용매추출물의 아질산염 소거 및 항돌연변이 효과 / 한국식품저장유통학회지 9(1):92~96
Bae YI / 1998 / Loquat(Eriobotrya japonica Lindl.) leaf tea processing and its physicochemical properties / Korean Journal of Postharvest Science and Technology 5:262~269
Bajko E / 2016 / 5-O-Caffeoylquinic acid : A spectroscopic study and biological screening for antimicrobial activity / LWT-Food Science and Technology 65:471~479
Cha DS / 2011 / Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica / Journal of Ethnopharmacology 134:305~312
조은경 / 2011 / 약용식물 복합 추출물 TMP1과 TMP2의 항산화능과 염증 억제 효과 / 생명과학회지 21(4):596~603
Bae YI / 1998 / Loquat(Eriobotrya japonica Lindl.) leaf tea processing and its physicochemical properties / Korean Journal of Postharvest Science and Technology 5:262~269
Bajko E / 2016 / 5-O-Caffeoylquinic acid : A spectroscopic study and biological screening for antimicrobial activity / LWT-Food Science and Technology 65:471~479
Cha DS / 2011 / Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica / Journal of Ethnopharmacology 134:305~312
조은경 / 2011 / 약용식물 복합 추출물 TMP1과 TMP2의 항산화능과 염증 억제 효과 / 생명과학회지 21(4):596~603
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UCI(KEPA) : I410-ECN-0101-2020-480-001160403