지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 741 - 762 (22page)
이용수
초록· 키워드
오류제보하기
Ginsenosides, the major active ingredients of ginseng, show a variety of biomedical efficacies such as anti-aging, anti oxidation and anti-inflammatory activities. To understand the effects of compound K (20-O-D-glucopyranosyl-20 (S)-protopanaxadiol), one of the major metabolite of ginsenosides on the skin, we assessed the expression level of ∼ 100 transcripts in compound K-treated HaCaT cells using cDNA microarray analysis. Compound K treatment induced differential expression of 21 genes, which have been reported to be involved in the organization of ECM structure as well as defense responses in human skin cells. One of the most interesting findings is 2-fold increase in hyaluronan synthase2 (HAS2) gene expression by compound K. We found that change in expression of HAS2 gene represents a specific response of HaCaT cells to compound K because hyaluronan synthase 1, 3 was not changed by treatment with compound K. We also demonstrated that the compound K effectively induced hyaluronan synthesis in human skin cells and hairless mouse skin. The human clinical study indicates that topical application of compound K-containing oil-in-water emulsion showed improvement of xerosis, wrinkle and fine lines in the aged skin. We concluded that compound K has anti-aging effects by the induction of HAS2 gene expression and following hyaluronan synthase.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
발아 검은쌀 올리고펩타이드의 각질형성세포에서 Hyaluronan Synthase 발현과 피부 탄력 개선 효과
대한화장품학회지
2006 .01
-
Hyaluronan Facilitates Invasion of Colon Carcinoma Cells in vitro via Interaction with CD44 and Hyaluronan Synthesis is Upregulated in Metastatic Colon Carcinoma Cells
대한외과학회 학술대회 초록집
2004 .10
-
돌나물추출물에 의한 사람 각질형성세포에서의 Hyaluronan Synthesis 촉진과 인체 피부의 보습력 증진
대한화장품학회지
2007 .01
-
Evaluation of the in vivo skin moisturizing effects and underlying mechanisms of pomegranate concentrate solution and dried pomegranate concentrate powder
대한한의학회지
2016 .06
-
The Effect of Hyaluronan Treatment in Endotoxemic Rats
Tuberculosis and Respiratory Diseases
2011 .01
-
추출 온도에 따른 금불초 꽃 추출물의 항노화 효능
대한화장품학회지
2014 .01
-
인체 피부 세포주 (HaCaT)에서 Kaempferol, Quercetin의 Hyaluronan 합성 촉진 효과에 대한 연구
대한화장품학회지
2005 .01
-
Synergistic effect of maclurin on ginsenoside compound K induced inhibition of the transcriptional expression of matrix metalloproteinase-1 in HaCaT human keratinocyte cells
Journal of Ginseng Research
2018 .04
-
낙타유가 함유된 리포좀 제조 및 피부 노화 개선 효과 연구
대한화장품학회지
2014 .01
-
치료하기 어려운 창상에서 하이알로매트릭스$^{(R)}$의 사용
대한성형외과학회지
2010 .01
-
피부 섬유아세포에서 광나무 추출물의 항 노화 효과
대한화장품학회지
2010 .01
-
Pharmacokinetics of ginsenoside Rb1 and its metabolite compound K after oral administration of Korean Red Ginseng extract
Journal of Ginseng Research
2013 .10
-
Ethanol Extract of Peanut Sprout Exhibits a Potent Anti-Inflammatory Activity in Both an Oxazolone-Induced Contact Dermatitis Mouse Model and Compound 48/80-Treated HaCaT Cells
Annals of Dermatology
2015 .01
-
Bioconversion of Ginsenoside Rd into Compound K by Lactobacillus pentosus DC101 Isolated from Kimchi
Journal of Ginseng Research
2010 .12
-
N.M.F.에 관한 고찰
대한화장품학회지
1970 .01
-
Compound K, Ginseng Saponin Metabolite, Induces Apoptosis in Human Monocytic Leukemia cells
한국응용약물학회 추계학술발표논문집
2003 .01
-
Effect of red ginseng NaturalGEL on skin aging
Journal of Ginseng Research
2020 .01
-
Carboxy Methyl화된 키토산이 토끼 슬관절의 골관절염에 미치는 효과 : Carboxy Methyl화된 키토산과 히알루론산의 비교
대한정형외과학회지
2005 .06
-
Structural Features of Polyphenolic Compounds in Their NO Inhibitory Activities
Biomolecules & Therapeutics(구 응용약물학회지)
2009 .01
-
Cytotoxicity of Compound K and Ginsenoside $R_{h2}$ against some tumor cells
대한약학회 학술대회
2003 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0