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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 288 - 295 (8page)
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초록· 키워드
오류제보하기
Ginsenosides are the principal components responsible for the pharmacological and biological activities of ginseng. Ginsenoside Rd was transformed into compound K using cell-free extracts of food microorganisms, with Lactobacillus pentosus DC101 isolated from kimchi (traditional Korean fermented food) used for this conversion. The optimum time for the conversion was about 72 h at a constant pH of 7.0 and an optimum temperature of about 30°C. The transformation products were identified by thin-layer chromatography and high-performance liquid chromatography, and their structures were assigned using nuclear magnetic resonance analysis. Generally, ginsenoside Rd was converted into ginsenoside F2 by 36 h post-reaction. Consequently, over 97% of ginsenoside Rd was decomposed and converted into compound K by 72 h post-reaction. The bioconversion pathway to produce compound K is as follows: ginsenoside Rd→ginsenoside F2→compound K.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (20)
참고문헌 신청
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Mochizuki M / 1995 / Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng / Biol Pharm Bull 18:1197~1202
Sato K / 1994 / Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2 / Biol Pharm Bull 17:635~639
Odani T / 1983 / Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. III. The absorption, distribution and excretion of ginsenoside Rb1 in the rat / Chem Pharm Bull 31:1059~1066
Paek IB / 2006 / Pharmacokinetics of a ginseng saponin metabolite compound K in rats / Biopharm Drug Dispos 27:39~45
Mochizuki M / 1995 / Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng / Biol Pharm Bull 18:1197~1202
Sato K / 1994 / Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2 / Biol Pharm Bull 17:635~639
Odani T / 1983 / Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. III. The absorption, distribution and excretion of ginsenoside Rb1 in the rat / Chem Pharm Bull 31:1059~1066
Paek IB / 2006 / Pharmacokinetics of a ginseng saponin metabolite compound K in rats / Biopharm Drug Dispos 27:39~45
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Transformation of Ginsenoside Rd into F2 and Compound K by Lactobacillus pentosus LH6 Isolated from Kimchi
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2008 .12
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Enzymatic Transformation of Ginsenoside Rb1 by Lactobacillus pentosus Strain 6105 from Kimchi
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2012 .07
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Lactobacillus brevis LH8이 생산하는 효소에 의한 Ginsenoside Rd의 Compound K로의 전환
Journal of Ginseng Research
2008 .09
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Ginsenoside Re로부터 20 ( R )- 및 20 ( S )- Ginsenoside RH_2_ 의 조제 ( Preparation of 20( R )- and 20( S )- Ginsenoside Rh_2_ from Ginsenoside Re )
Journal of Ginseng Research
1991 .12
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Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3
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2014 .01
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Bioconversion of ginsenoside Rb1 into compound K by Leuconostoc mesenteroides LH2 isolated from Kimchi
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2009 .12
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Ginsentology II : Chemical Structure-Biological Activity Relationship of Ginsenoside
Journal of Ginseng Research
2007 .06
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Cytotoxicity of Compound K (IH-901) and Ginsenoside Rh2, Main Biotransformants of Ginseng Saponins by Bifidobacteria, against Some Tumor Cells
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2003 .09
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Ginsenoside의 새로운 분리 · 정제방법 ( New Efficient Method for Isolation and Purification of Ginsenosides )
Journal of Ginseng Research
1998 .12
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Variations in Ginsenosides of Raw Ginseng According to Heating Temperature and Time
Journal of Pharmacopuncture
2020 .01
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Non-clinical pharmacokinetic behavior of ginsenosides
Journal of Ginseng Research
2019 .06
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Ginsenoside profiles and related gene expression during foliation in Panax ginseng Meyer
Journal of Ginseng Research
2014 .01
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쥐 간에서의 Ginsenoside의 세포내 분포와 대사 ( Cellular Distribution and Metabolism of Ginsenosides in Rat Liver )
Journal of Ginseng Research
1993 .08
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Bioconversion of ginsenoside Rb1 into F₂ by Lactobacillus sakei LH1 isolated from Kimchi
고려인삼학회 학술대회
2009 .05
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(20s) Ginsenoside Rh2 suppress colorectal cancer cell growth by Axl signal pathway in vitro and in vivo
한국실험동물학회 학술발표대회 논문집
2020 .07
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Influence of organic acids and heat treatment on ginsenoside conversion
Journal of Ginseng Research
2018 .10
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Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans
Journal of Ginseng Research
2011 .09
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Microbial Conversion of Major Ginsenoside Rb1 to Minor Ginsenoside C-K by Flavobacterium sp. THG-176 Isolated from Pine Field Soil
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2011 .04
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UCI(KEPA) : I410-ECN-0101-2012-524-004168170