Serum Procollagen Type I N-Terminal Propeptide and Osteocalcin Levels in Korean Children and Adolescents

Ji Seon Choi; Ikchun Park; LEE SOO JUNG; Ju， Hyo-Jin; Hyeyoung Lee; Jayoung Kim

Serum Procollagen Type I N-Terminal Propeptide and Osteocalcin Levels in Korean Children and Adolescents

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Type: Academic journal

Author: Ji Seon Choi Ikchun Park LEE SOO JUNG Ju， Hyo-Jin Hyeyoung Lee Jayoung Kim

Journal: Yonsei University College of Medicine Yonsei Medical Journal Yonsei Medical Journal 제60권 제12호 KCI Accredited Journals

Published: 2019.1

Pages: 1,174 - 1,180 (7page)

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Serum Procollagen Type I N-Terminal Propeptide and Osteocalcin Levels in Korean Children and Adolescents

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Purpose: Bone markers can be useful for the diagnosis and treatment of skeletal diseases in children and adolescents. Owing tohigh skeletal growth velocity and rapid bone turnover, children and adolescents have higher bone marker levels than adults. Thus, a valid age- and sex-specific reference should be established for pediatric populations living in similar environments. Weaimed to assess the associations of procollagen type I N-terminal propeptide (P1NP) and osteocalcin with age and sex in a groupof healthy Korean children and adolescents. Materials and Methods: The participants (290 boys and 290 girls, age range 0–18 years) were Korean outpatients. Serum P1NPand osteocalcin levels were measured in control materials and patient samples by electrochemiluminescence immunoassay usingan automated Cobas e411 analyzer. Results: Significant age-dependent variations in bone marker levels were observed in both sexes (p<0.001). The highest P1NPlevels were observed during the first year of life; thereafter, levels decreased until puberty. There was no postnatal peak for osteocalcin;however, its levels remained higher than the adult reference range throughout childhood. Significant differences were observedbetween boys and girls (p<0.05), especially between the ages of 12 and 17 years. Cobas e411 results for P1NP showed satisfactoryprecision and linearity. Conclusion: We established reference data for P1NP and osteocalcin levels in healthy Korean children and adolescents, as thefirst and only study of these parameters in pre-adulthood in Korea. Cobas e411-quantified bone markers may be useful for determiningbone metabolism indices.

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