지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Untreated hyperthyroidism and high-dose thyroid hormone are associated with osteoporosis, and increased bone mineral density (BMD) has been demonstrated in postmenopausal females with hypoparathyroidism. Studies on the effect of suppressive levothyroxine (LT4) therapy on BMD and bone metabolism after total thyroidectomy in patients with differentiated thyroid carcinoma have presented conflicting results, and few studies in relation to the status of hypoparathyroidism have been studied. One hundred postmenopausal women and 24 premenopausal women on LT4 suppression therapy were included in this study. BMD of lumbar spine and femur and bone turnover markers were measured at the baseline and during the follow-up period up to 18 months using dual energy X-ray absorptiometry. Biochemical marker of bone resorption was measured by urine deoxypyridinoline and bone formation by serum osteocalcin.
The age ranged from 36 to 64 years old. Thyroid stimulating hormone (TSH) was suppressed during the study. The results showed that BMD of femur and lumbar spine were not significantly changed in both pre- and postmenopausal women except femur neck in postmenopausal women without hypoparathyroidism. Patients with hypoparathyroidism had higher BMD gain than those without hypoparathyroidism in total hip (1.25 vs. -1.18%, P=0.015). Biochemical markers of bone turnover, serum osteocalcin, and urine deoxypyridinoline did not show significant change. In conclusion, patients with well differentiated thyroid carcinoma are not at a great risk of bone loss after LT4 suppressive therapy. The state of hypoparathyroidism is associated with increased BMD, particularly in postmenopausal women.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Brito JP / 2014 / Is there really an increased incidence of thyroid cancer? / Curr Opin Endocrinol Diabetes Obes 21 : 405 ~ 408
Chan FK / 2003 / Increased bone mineral density in patients with chronic hypoparathyroidism / J Clin Endocrinol Metab 88 : 3155 ~ 3159
Chapuy MC / 1992 / Vitamin D3 and calcium to prevent hip fractures in the elderly women /
Cooper DS / 1998 / Thyrotropin suppression and disease progression in patients with differentiated thyroid cancer: results from the National Thyroid Cancer Treatment Coopera
Cooper DS / 2009 / Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 19 : 1167 ~ 1214
Chan FK / 2003 / Increased bone mineral density in patients with chronic hypoparathyroidism / J Clin Endocrinol Metab 88 : 3155 ~ 3159
Chapuy MC / 1992 / Vitamin D3 and calcium to prevent hip fractures in the elderly women /
Cooper DS / 1998 / Thyrotropin suppression and disease progression in patients with differentiated thyroid cancer: results from the National Thyroid Cancer Treatment Coopera
Cooper DS / 2009 / Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 19 : 1167 ~ 1214
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Influence of Thyroid-stimulating Hormone Suppression Therapy on Bone Mineral Density in Patients with Differentiated Thyroid Cancer: A Meta-analysis
대한골대사학회지
2019 .01
-
젊은 한국인 여성에서 골밀도와 갑상선 자극호르몬과의 연관성
OSTEOPOROSIS
2015 .01
-
Evaluation and Management of Bone Health in Patients with Thyroid Diseases: A Position Statement of the Korean Thyroid Association
Endocrinology and Metabolism
2023 .04
-
Evaluation of Bone Density Measurement in Type 2 Diabetic Postmenopausal Women with Hypertension and Hyperlipidemia
대한폐경학회지
2015 .01
-
Bone Mineral Density in Thyroid Cancer Patients: Data from the Korea National Health and Nutrition Examination Survey
The Journal of Endocrine Surgery
2017 .01
-
여성의 생애주기별 골건강 문제 및 골밀도 영향요인: 2010년 국민건강영양조사 자료 이용
Women's Health Nursing
2015 .01
-
Impaired Quality of Life in Patients with Post-Surgical Hypoparathyroidism
대한골대사학회지
2024 .05
-
Modulation of Bone Mineral Density and Its Response to Menopausal Hormone Therapy according to the Apolipoprotein E Genotype in Postmenopausal Korean Women
대한폐경학회지
2024 .04
-
The Changes of CTX, DPD, Osteocalcin, and Bone Mineral Density During the Postmenopausal Period
Annals of Rehabilitation Medicine
2018 .01
-
Bone microarchitecture and bone mineral density in Graves’ disease
Osteoporosis and Sarcopenia
2023 .06
-
Low bone mineral density in children and adolescents with cancer
Annals of Pediatirc Endocrinology & Metabolism
2020 .01
-
Effects of Combination Therapy of Alendronate and Hormonal Therapy on Bone Mineral Density in Postmenopausal Korean Women: Multicenter, Randomized Controlled Clinical Trial
Journal of Korean Medical Science
2017 .01
-
갑상선내분비 I Management of Hypoparathyroidism after Thyroid Surgery
대한외과학회 학술대회 초록집
2022 .05
-
Breast Feeding Is Associated with Postmenopausal Bone Loss: Findings from the Korea National Health and Nutrition Examination Survey
Korean Journal of Family Medicine
2015 .01
-
The Relationship between Renal Function and Bone Marrow Density in Healthy Korean Women
대한폐경학회지
2017 .08
-
Changes in bone mineral density in unconscious immobile stroke patients from the acute to chronic phases of brain diseases
Osteoporosis and Sarcopenia
2022 .09
-
갑상선자극호르몬이 골대사에 미치는 영향
International Journal of Thyroidology
2016 .01
-
Effects of Hormone Replacement Therapy on Bone Mineral Density in Korean Adults With Turner Syndrome
Journal of Korean Medical Science
2024 .01
-
갑상선기능 이상이 골대사에 미치는 영향
International Journal of Thyroidology
2018 .01
-
Relationship between Serum Inflammatory Marker and Bone Mineral Density in Healthy Adults
대한골대사학회지
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0