지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: The objective was to determine the association between PaCO2 and adverse cardiovascular events (ACVEs) in carbon monoxide (CO)-poisoned patients. Methods: This retrospective study included 194 self-breathing patients after CO poisoning with an indication for hyperbaric oxygen therapy and available arterial blood gas analysis at presentation and 6 hours later. The baseline characteristics and clinical course during hospitalization were collected and compared. The mean PaCO2 during the first 6 hours after presentation was calculated. Results: The incidence rates of moderate (30 mmHg< PaCO2 <35 mmHg) or severe (PaCO2 ≤30 mmHg) hypocapnia at presentation after acute CO poisoning were 40.7% and 26.8%, respectively. The mean PaCO2 during the first 6 hours was 33 (31-36.7) mmHg. The incidence of ACVEs during hospitalization was 50.5%. A significant linear trend in the incidence of ACVEs was observed across the total ranges of PaCO2 variables. In multivariate regression analysis, mean PaCO2 was independently associated with ACVEs (OR 0.798 (95% CI 0.641-0.997)). Conclusion: Mean PaCO2 during the first 6 hours was associated with increased ACVEs. Given the high incidence of ACVEs and PaCO2 derangement and the observed association between PaCO2 and ACVEs, this study suggests that 1) PaCO2 should be monitored at the acute stage to predict and/or prevent ACVEs; and 2) further study is needed to validate this result and investigate early manipulation of PaCO2 as treatment.
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참고문헌 (18)
참고문헌 신청
Lippi G / 2012 / Pathophysiology, clin-ics, diagnosis and treatment of heart involvement in carbon monoxide poisoning / Clin Biochem 45:1276~1285
Kao HK / 2009 / Assessment of myocardial injury in the emergency department independently predicts the short-term poor outcome in patients with severe carbon monoxide poisoning receiving mechanical ventilation and hyperbaric oxygen therapy / Pulm Pharmacol Ther 22(6):473~477
Henry CR / 2006 / Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning / JAMA 295(4):398~402
Crystal GJ / 2015 / Carbon dioxide and the heart : physiology and clinical implications / Anesth Analg 121:610~623
Aslan S / 2006 / The evaluation of myocardial damage in 83 young adults with carbon monoxide poisoning in the East Anatolia region in Turkey / Hum Exp Toxicol 25:439~446
Kao HK / 2009 / Assessment of myocardial injury in the emergency department independently predicts the short-term poor outcome in patients with severe carbon monoxide poisoning receiving mechanical ventilation and hyperbaric oxygen therapy / Pulm Pharmacol Ther 22(6):473~477
Henry CR / 2006 / Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning / JAMA 295(4):398~402
Crystal GJ / 2015 / Carbon dioxide and the heart : physiology and clinical implications / Anesth Analg 121:610~623
Aslan S / 2006 / The evaluation of myocardial damage in 83 young adults with carbon monoxide poisoning in the East Anatolia region in Turkey / Hum Exp Toxicol 25:439~446
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