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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 37 - 44 (8page)
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This study aimed to investigate the effect of pomegranate extract (PE) on the progression of periodontal disease in an experimental rat model of periodontitis. Periodontitis was induced in rats by placing a 5-0 black silk ligature and injecting a lipopolysaccharide of Porphyromonas gingivalis into the gingiva. Distilled water (DW) or PE solution was orally administered daily, and the animals were sacrificed after 3 weeks. Tissue specimens of the periodontitis model were analyzed using an enzyme-linked immunosorbent assay kit and by micro-computed tomography (CT) imaging. The expression levels of cyclo-oxygenase (COX)-1 and COX-2 were significantly reduced in ligation (Lig)+PE 22 µg/mL and Lig+PE 44 µg/mL groups, but there was no statistically significant difference in matrix metalloproteinase (MMP)-8 levels. Furthermore, micro-CT imaging demonstrated that alveolar bone resorption was inhibited in Lig+PE 22 µg/mL and Lig+PE 44 µg/mL groups compared with that in the Lig+DW group. These results demonstrate that PE has an inhibitory effect on the progression of alveolar bone loss caused by periodontal inflammation by reducing the expression levels of COX-1 and COX-2 in the process of periodontal disease.
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참고문헌 (34)
참고문헌 신청
Rajan S / 2013 / Hidden secrets of ‘Punica granatum’ use and its effects on oral health : a short review / J Orofac Res 3:38~41
Pereira JV / 2006 / In vitro antibacterial and antiadherence effect of the extract of the Punica granatum Linn. Upon dental biofilm microrganisms / Rev Bras Farmacogn 16:88~93
Masaud IA / 2014 / Potential of therapeutic antioxidant compounds from pomegranate as anti-cancer agent / J Chem Pharm Res 6:427~433
Dahham SS / 2010 / Studies on antibacterial and antifungal activity of pomegranate (Punica granatum L.) / American-Eurasian J Agric Environ Sci 9:273~281
Seeram NP / 2005 / In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice / J Nutr Biochem 16:360~367
Pereira JV / 2006 / In vitro antibacterial and antiadherence effect of the extract of the Punica granatum Linn. Upon dental biofilm microrganisms / Rev Bras Farmacogn 16:88~93
Masaud IA / 2014 / Potential of therapeutic antioxidant compounds from pomegranate as anti-cancer agent / J Chem Pharm Res 6:427~433
Dahham SS / 2010 / Studies on antibacterial and antifungal activity of pomegranate (Punica granatum L.) / American-Eurasian J Agric Environ Sci 9:273~281
Seeram NP / 2005 / In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice / J Nutr Biochem 16:360~367
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