지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: Periodontitis is an inflammatory disease with the destruction of periodontal ligament, alveolar bone loss and inflammation of gingva, leading to teeth loss. Eclipta prostrata L. (Ecliptae Herba) has been used to treat the inflammatory disease as a Korean traditional medicine. The aim of this study is to investigate the effects of E. prostrata L. on periodontitis.
Methods: E. prostrata L. was extracted with water and lyophilized. The aqueous extract of E. prostrata L. (EP) was topically applied to the periodontal lesion for 2 weeks. To induce the periodontitis, a 3-0 nylon ligature was placed around the cervix of the lower first molar in rat. Rats were divided into 3 groups (n = 7); NL group (non-ligatured and non-treated), L group (ligatured and vehicle-treated) and EP group (ligatured and EP-treated). After sacrifice, the mandibles was dissected and stained with methylene blue solution to analyze the alveolar bone loss. The expression of MMP-9 was determined in gingival tissues. To confirm the effect of EP on recovery of gingiva, mRNA expressions of type I pro-collagen and MMP-9 levels were investigated in LPS-treated HS68 fibroblast cells. In addition, inflammatory mediators were evaluated in LPS-treated RAW264.7 cells.
Results: Alveolar bone loss was significantly inhibited by EP treatment. The mRNA expression of MMP-9 was attenuated in rats treated with EP. In addition, treatment with EP increased the expression of type I pro-collagen, while the expression of MMP-9 was decreased in LPS-stimulated HS68 fibroblast cells. Furthermore, EP down-regulated the LPS-induced IL-6, TNF-α, COX-2 and iNOS production in RAW264.7 cells.
Conclusions: These results suggest that EP have ameliorative effects on periodontitis through inhibiting alveolar bone loss and modulating the inflammatory mediators. Therefore, E. prostrata L. may be an alternative on patients with periodontitis.
Methods: E. prostrata L. was extracted with water and lyophilized. The aqueous extract of E. prostrata L. (EP) was topically applied to the periodontal lesion for 2 weeks. To induce the periodontitis, a 3-0 nylon ligature was placed around the cervix of the lower first molar in rat. Rats were divided into 3 groups (n = 7); NL group (non-ligatured and non-treated), L group (ligatured and vehicle-treated) and EP group (ligatured and EP-treated). After sacrifice, the mandibles was dissected and stained with methylene blue solution to analyze the alveolar bone loss. The expression of MMP-9 was determined in gingival tissues. To confirm the effect of EP on recovery of gingiva, mRNA expressions of type I pro-collagen and MMP-9 levels were investigated in LPS-treated HS68 fibroblast cells. In addition, inflammatory mediators were evaluated in LPS-treated RAW264.7 cells.
Results: Alveolar bone loss was significantly inhibited by EP treatment. The mRNA expression of MMP-9 was attenuated in rats treated with EP. In addition, treatment with EP increased the expression of type I pro-collagen, while the expression of MMP-9 was decreased in LPS-stimulated HS68 fibroblast cells. Furthermore, EP down-regulated the LPS-induced IL-6, TNF-α, COX-2 and iNOS production in RAW264.7 cells.
Conclusions: These results suggest that EP have ameliorative effects on periodontitis through inhibiting alveolar bone loss and modulating the inflammatory mediators. Therefore, E. prostrata L. may be an alternative on patients with periodontitis.
목차
서론
실험 재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (39)
참고문헌 신청
[학술지(정기간행물)] - Petersen PE / 2012 / The global burden of periodontal disease: towards integration with chronic disease prevention and control / Periodontology 2000 60 (1) : 15 ~ 39
[학술지(정기간행물)] - Renvert S / 2002 / A systematic review on the use of residual probing depth, bleeding on probing and furcation status following initial periodontal therapy to predict further attachment and tooth loss / Journal of clinical periodontology 29 (3) : 82 ~ 89
[단행본] - / 2015 / Korea National Health and Nutrition Examination Survey
[학술지(정기간행물)] - Bartold PM / 2013 / Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts / Periodontology 2000 62 (1) : 203 ~ 217
[학술지(정기간행물)] - Socransky SS / 1994 / Evidence of bacterial etiology: a historical perspective / Periodontology 2000 5 (1) : 7 ~ 25
[학술지(정기간행물)] - Renvert S / 2002 / A systematic review on the use of residual probing depth, bleeding on probing and furcation status following initial periodontal therapy to predict further attachment and tooth loss / Journal of clinical periodontology 29 (3) : 82 ~ 89
[단행본] - / 2015 / Korea National Health and Nutrition Examination Survey
[학술지(정기간행물)] - Bartold PM / 2013 / Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts / Periodontology 2000 62 (1) : 203 ~ 217
[학술지(정기간행물)] - Socransky SS / 1994 / Evidence of bacterial etiology: a historical perspective / Periodontology 2000 5 (1) : 7 ~ 25
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