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논문 기본 정보

자료유형
학술저널
저자정보
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한국스포츠학회 한국스포츠학회 한국스포츠학회 제17권 제4호
발행연도
2019.1
수록면
925 - 932 (8page)

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Using rats exposed prenatally to valproic acid (VPA) as an animal model, we measured expression of 5-HT and TPH in samples collected from the dorsal raphe using the immunohistochemistry. The basal 5-HT and TPH expression level in raphe was significantly higher in VPA-exposed rats relative to controls. Since the over-expression of 5-HT and TPH system is known to be sensitive to physical and psychological stressors, we measured expression 5-HT and TPH levels in raphe nucles after chronic swimming exercise. There were further gradual decreased in hyperserotonemia expression 5-HT and TPH levels during the swimming exercise in the VPA-exposed rats and the level of serotonine decreased in the control rats. The expression 5-HT and TPH revealed a significant decrease in exercise with autism-treated rats. These results suggest that this rodent model of autism exhibits a high expression 5-HT and TPH, which is inhibited by swim exercise. This abnormality may be responsible for anxiety and withdrawal behavior observed in autism. Based on these present results, swimming exercise may be a useful strategy to decrease the hyperserotoninemia such as overexpression 5-HT and TPH of the pups born from mothers who have exposed VPA-treated rats during pregnancy.

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