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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 73 - 78 (6page)
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Purpose: Testing for autoantibodies to extractable nuclear antigens (ENAs) plays an important role in the diagnosis and managementof systemic rheumatic disease. Currently, no gold standard tests are available for detecting anti-ENAs. To address this gap, weaimed to identify an assay that exhibits satisfactory diagnostic performance in the detection of five common anti-ENAs by comparingtwo commonly used assays, an automated fluorescent enzyme immunoassay (FEIA) and a microplate ELISA assay. Materials and Methods: Sera from 100 patients with systemic rheumatic disease were collected and assayed with FEIA and microplateELISA to detect anti-ENAs. Statistical analyses were performed to check the agreement rate between the two platformsusing kappa coefficients. Analytical sensitivity and specificity for each assay were calculated. Results: The concordance rates between ELISA and FEIA ranged from 89% for anti-RNP to 97% for anti-Scl-70, and the kappa coefficientsof the two assays were in the range of 0.44 to 0.82. Between the two assays, a significant difference in sensitivity and specificitywas seen only for anti-Sm and anti-RNP, respectively. Conclusion: In this study, FEIA and ELISA showed comparable efficiency for detecting anti-ENAs.
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참고문헌 (21)
참고문헌 신청
Egner W / 2000 / The use of laboratory tests in the diagnosis of SLE / J Clin Pathol 53:424~432
van Venrooij WJ / 1991 / The consensus workshops for the detection of autoantibodies to intracellular antigens in rheumatic diseases / J Immunol Methods 140:181~189
Catoggio LJ / 1983 / Serological markers in progressive systemic sclerosis : clinical correlations / Ann Rheum Dis 42:23~27
Kayser C / 2015 / Autoantibodies in systemic sclerosis : unanswered questions / Front Immunol 6:167
Migliorini P / 2005 / Anti-Sm and anti-RNP antibodies / Autoimmunity 38:47~54
van Venrooij WJ / 1991 / The consensus workshops for the detection of autoantibodies to intracellular antigens in rheumatic diseases / J Immunol Methods 140:181~189
Catoggio LJ / 1983 / Serological markers in progressive systemic sclerosis : clinical correlations / Ann Rheum Dis 42:23~27
Kayser C / 2015 / Autoantibodies in systemic sclerosis : unanswered questions / Front Immunol 6:167
Migliorini P / 2005 / Anti-Sm and anti-RNP antibodies / Autoimmunity 38:47~54
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