지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 550 - 554 (5page)
이용수
초록· 키워드
오류제보하기
Background: Anti-hepatitis C virus antibody (anti-HCV) assays are recommended for screening HCV-infected persons. The VIDAS Anti-HCV Assay (bioMérieux, France), based on the enzyme-linked fluorescence test principle, was recently introduced in Korea. We evaluated the clinical performance of the VIDAS assay.
Methods: One hundred HCV-positive and 1,002 HCV-negative blood samples confirmed by Architect anti-HCV (Abbott Laboratories, USA) and COBAS TaqMan HCV real-time PCR (Roche Diagnostics, USA) or the Procleix Ultrio Plus Assay (Gen-Probe Incorporated, USA) were obtained from the Human Serum Bank (HSB) and tested by VIDAS. In case of discrepant results, we conducted a recombinant immunoblot assay (RIBA).
Results: The agreement rates for known HCV-positive and HCV-negative samples between the VIDAS assay and the HSB testing were 100% (95% confidence interval [CI]: 96.4-100%) and 99.5% (95% CI: 98.8-99.8%), respectively. One of the five discrepant samples was positive for Core 2+ and NS3-2 2+ reactivity, two samples were negative, and the other two were indeterminate regarding NS4 2+ reactivity in RIBA. We observed a significant but weak positive correlation between the titers of VIDAS and Architect assays (r=0.315, P<0.001).
Conclusions: The VIDAS anti-HCV assay, developed on the VIDAS automated immunoassay platform based on the ready-to-use, single-sample test concept may be useful in small-to-medium-sized laboratories. It showed good agreement with Architect anti-HCV and COBAS PCR assays and is therefore useful for detection of HCV infection. Weakly test-positive (ambiguous) samples require additional testing by another anti-HCV, RIBA, or HCV RNA assay.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
WHO / Hepatitis C
WHO / Guidelines for the screening care and treatment of persons with hepatitis c infection
European Association for Study of L / 2014 / EASL Clinical Practice Guidelines: management of hepatitis C virus infection / J Hepatol 60:392~420
Kamili S / 2012 / Laboratory diagnostics for hepatitis C virus infection / Clin Infect Dis 55(Sl):S43~S48
Seignères B / 2016 / Multicenter clinical evaluation of the new 3rd generation assay for detection of antibodies against hepatitis C virus on the VIDAS system / J Clin Virol 78:20~26
WHO / Guidelines for the screening care and treatment of persons with hepatitis c infection
European Association for Study of L / 2014 / EASL Clinical Practice Guidelines: management of hepatitis C virus infection / J Hepatol 60:392~420
Kamili S / 2012 / Laboratory diagnostics for hepatitis C virus infection / Clin Infect Dis 55(Sl):S43~S48
Seignères B / 2016 / Multicenter clinical evaluation of the new 3rd generation assay for detection of antibodies against hepatitis C virus on the VIDAS system / J Clin Virol 78:20~26
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Prevalence, Awareness, and Treatment of Hepatitis C Virus Infection in South Korea: Evidence from the Korea National Health and Nutrition Examination Survey
Gut and Liver
2020 .01
-
Cost-effectiveness of chronic hepatitis C screening and treatment
Clinical and Molecular Hepatology
2022 .04
-
Clinical Utility of a New Automated Hepatitis C Virus Core Antigen Assay for Prediction of Treatment Response in Patients with Chronic Hepatitis C
Journal of Korean Medical Science
2016 .01
-
Influence of Test Parameters on the Performance of Rapid Anti-Hepatitis C Virus Immunochromatographic Assay
Journal of Laboratory Medicine And Quality Assurance
2021 .01
-
The Korean Hepatitis C Virus Care Cascade in a Tertiary Institution: Current Status and Changes in Testing, Link to Care, and Treatment
Gut and Liver
2022 .11
-
The Role of the Signal-to-Cutoff Ratio in Automated Anti-HCV Chemiluminescent Immunoassays by Referring to the Nucleic Acid Amplification Test and the Recombinant Immunoblot Assay
Annals of Laboratory Medicine
2018 .01
-
The Applications of Hepatitis C Virus (HCV) Replication System in Developing Anti-HCV Reagents
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .06
-
Hepatitis C Viral Infection in Children: Updated Review
Pediatric Gastroenterology, Hepatology & Nutrition
2016 .01
-
Hepatocytes infected with hepatitis C virus change immunological features in the liver microenvironment
Clinical and Molecular Hepatology
2023 .01
-
Clinical Characteristics and Treatment Outcomes of Patients with Hepatitis C Virus and Human Immunodeficiency Virus Coinfection: Experience at a Single Center in Korea
Journal of Korean Medical Science
2021 .11
-
A Survey of the Knowledge of and Testing Rate for Hepatitis C in the General Population in South Korea
Gut and Liver
2020 .01
-
C형 간염의 역학
대한내과학회지
2015 .01
-
HCV 핵산증폭검사 양성 헌혈 혈액의 바이러스 유전자 정량 및 유전자형 분석
대한수혈학회지
2019 .01
-
농축기술을 이용한 HCV 저역가 감염혈액의 유전자형 분석
대한수혈학회지
2021 .01
-
Scaling up the in-hospital hepatitis C virus care cascade in Taiwan
Clinical and Molecular Hepatology
2021 .01
-
Differences in Hematological Characteristics, Including Cholesterol and Apolipoprotein B and E, between Hepatitis B Virus and Hepatitis C Virus Patients in Korea
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .09
-
Reactivation of Hepatitis C Virus and Its Clinical Outcomes in Patients Treated with Systemic Chemotherapy or Immunosuppressive Therapy
Gut and Liver
2017 .01
-
HCV treatment focusing on LT candidates/recipients
한국간담췌외과학회 학술대회지
2016 .04
-
miR-215 Enhances HCV Replication by Targeting TRIM22 and Inactivating NF-κB Signaling
Yonsei Medical Journal
2018 .01
-
Depletion of MicroRNA-373 Represses the Replication of Hepatitis C Virus via Activation of Type 1 Interferon Response by Targeting IRF5
Yonsei Medical Journal
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0