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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 85 - 93 (9page)
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Purpose: The aim of this study was to investigate the effect of FST gene on the inhibition of fibrosis in fibroblastic cells from scartissue around repaired zone II flexor tendons. Materials and Methods: Immunohistochemistry was conducted on fibroblast cells transfected with adenovirus-LacZ (Ad-LacZ)as a marker gene (control), or with adenovirus-FST (Ad-FST) as a therapeutic gene. Fibroblast cultures without adenoviral exposureserved as controls. Results: Fibroblastic cells transfected with Ad-FST demonstrated significant decrease in collagen type I, MMP-1, MMP2, andα-SMA mRNA expressions compared to those transfected with Ad-LacZ. In addition, fibroblastic cells transfected with Ad-FSTexhibited significant decrease in MMP-1, TIMP-1, fibronectin, PAI-1, TRPV4, α-SMA, desmin, and PAX7 protein expressions. Conclusion: Based on these findings, we conclude that FST may be a novel therapeutic strategy for preventing scar adhesionsaround repaired tendons by inhibiting fibroblasts from differentiating into myofibroblasts, in addition to producing type I collagenand regulating extracellular matrix turnover via the downregulation of MMP-1 and TIMP-1. FST may also decrease contractureof the scar by inhibiting Ca2+-dependent cell contraction.
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참고문헌 (38)
참고문헌 신청
Clayton RA / 2008 / The epidemiology of musculoskeletal tendinous and ligamentous injuries / Injury 39:1338~1344
Dy CJ / 2012 / The epidemiology of reoperation after flexor tendon repair / J Hand Surg Am 37:919~924
Dy CJ / 2012 / Complications after flexor tendon repair : a systematic review and metaanalysis / J Hand Surg Am 37:543~551
Hill C / 1998 / A regional audit of hand and wrist injuries. A study of 4873 injuries / J Hand Surg Br 23:196~200
Tang JB / 2018 / New developments are improving flexor tendon repair / Plast Reconstr Surg 141:1427~1437
Dy CJ / 2012 / The epidemiology of reoperation after flexor tendon repair / J Hand Surg Am 37:919~924
Dy CJ / 2012 / Complications after flexor tendon repair : a systematic review and metaanalysis / J Hand Surg Am 37:543~551
Hill C / 1998 / A regional audit of hand and wrist injuries. A study of 4873 injuries / J Hand Surg Br 23:196~200
Tang JB / 2018 / New developments are improving flexor tendon repair / Plast Reconstr Surg 141:1427~1437
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