지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 415 - 422 (8page)
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초록· 키워드
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Purpose: The aim of this study was to investigate the anti-fibrotic effect of relaxin in subsynovial fibroblasts activated by transforminggrowth factor beta (TGF-β).
Materials and Methods: To test the anti-fibrotic effect of an adenovirus-relaxin construct (Ad-RLN) on subsynovial fibroblasts in vitro, cells from subsynovial connective tissue of patients with carpal tunnel syndrome were activated with TGF-β1 and exposed to Ad-RLN (as a therapeutic gene) or adenovirus-lacZ construct (as a marker gene) for four hours. Subsynovial fibroblast cultures without adenoviral exposure served as controls.
Results: We observed induction of gene expressions of collagen I, III and IV, as well as the abatement of alpha-smooth muscle actin(a-SMA) synthesis, Smad2 phosphorylation, and fibronectin at the protein level, in comparison to controls. In addition, proteinexpressions of matrix metalloproteinase (MMP) I was significantly induced, whereas the protein expressions of tissue inhibitorof metalloproteinases (TIMP) I and IV were reduced due to relaxin expression.
Conclusion: RLN prevents excessive synthesis of extracellular matrix by reducing the expressions of its components, such as fibronectin,a-SMA, and phosphorylated Smad2, by increasing the expression of MMPs; and by decreasing the expression of TIMPs.
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참고문헌 (23)
참고문헌 신청
Armstrong TJ / 1984 / Some histological changes in carpal tunnel contents and their biomechanical implications / J Occup Med 26 : 197 ~ 201
Ettema AM / 2004 / A histological and immunohistochemical study of the subsynovial connective tissue in idiopathic carpal tunnel syndrome / J Bone Joint Surg Am 86-A : 1458 ~
Ettema AM / 2006 / Changes in the functional structure of the tenosynovium in idiopathic carpal tunnel syndrome: a scanning electron microscope study / Plast Reconstr Surg 11
Ettema AM / 2006 / Comparative anatomy of the subsynovial connective tissue in the carpal tunnel of the rat, rabbit, dog, baboon, and human / Hand (N Y) 1 : 78 ~ 84
Ettema AM / 2008 / Flexor tendon and synovial gliding during simultaneous and single digit flexion in idiopathic carpal tunnel syndrome / J Biomech 41 : 292 ~ 298
Ettema AM / 2004 / A histological and immunohistochemical study of the subsynovial connective tissue in idiopathic carpal tunnel syndrome / J Bone Joint Surg Am 86-A : 1458 ~
Ettema AM / 2006 / Changes in the functional structure of the tenosynovium in idiopathic carpal tunnel syndrome: a scanning electron microscope study / Plast Reconstr Surg 11
Ettema AM / 2006 / Comparative anatomy of the subsynovial connective tissue in the carpal tunnel of the rat, rabbit, dog, baboon, and human / Hand (N Y) 1 : 78 ~ 84
Ettema AM / 2008 / Flexor tendon and synovial gliding during simultaneous and single digit flexion in idiopathic carpal tunnel syndrome / J Biomech 41 : 292 ~ 298
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