메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Bahar Bektan Kanat (Division of Geriatric Medicine Department of Internal Medicine Cerrahpasa Faculty of Medicine Istanbul University-Cerrahpasa Istanbul Turkey) Gulru Ulugerger Avci (Division of Geriatric Medicine Department of Internal Medicine Cerrahpasa Faculty of Medicine Istanbul University-Cerrahpasa Istanbul Turkey) Osman Faruk Bayramlar (Bakırkoy District Health Directorate Turkish Ministry of Health Istanbul Turkey) Damla Unal (Division of Geriatric Medicine Department of Internal Medicine Cerrahpasa Faculty of Medicine Istanbul University-Cerrahpasa Istanbul Turkey) Ozge Sonmez (Department of Internal Medicine Cerrahpasa Faculty of Medicine Istanbul University-Cerrahpasa Istanbul Turkey) Ibrahim Murat Bolayirli (Department of Biochemistry Cerrahpasa Faculty of Medicine Istanbul University-Cerrahpasa Istanbul Turkey) Alper Doventas (Division of Geriatric Medicine Department of Internal Medicine Cerrahpasa Faculty of Medicine Istanbul University-Cerrahpasa Istanbul Turkey) Deniz Suna Erdincler (Division of Geriatric Medicine Department of Internal Medicine Cerrahpasa Faculty of Medicine Istanbul University-Cerrahpasa Istanbul Turkey) Hakan Yavuzer (Division of Geriatrics Department of Internal Medicine Faculty of Cerrahpasa Medicine Istanbul University-Cerrahpasa Istanbul 34098 Turkey.)
저널정보
대한노인병학회 Annals of geriatric medicine and research Annals of geriatric medicine and research Vol.27 No.2
발행연도
2023.6
수록면
151 - 157 (7page)
DOI
10.4235/agmr.23.0024

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background: Matrix metalloproteinases (MMPs) play an important role in bone resorption and are regulated by tissue inhibitors of metalloproteinases (TIMPs). We investigated the use of MMP2/TIMP2 and MMP9/TIMP1 ratios as biomarkers of bone resorption in geriatric osteoporosis and evaluated the relationship between osteoporosis and geriatric syndromes. Methods: This analytical cross-sectional study involved 87 patients (41 with osteoporosis) treated at the geriatric outpatient clinic of a university hospital. The demographic characteristics, comprehensive geriatric assessment scores, laboratory findings, and bone mineral density of the patients were recorded. Serum MMP9, TIMP1, MMP2, and TIMP2 levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: We enrolled 41 and 46 patients with and without osteoporosis, respectively. The groups showed no significant differences in MMP2/TIMP2 and MMP9/TIMP1 ratios (p=0.569 and p=0125, respectively). While the basic activities of daily life (BADL) scores in the osteoporosis group were higher than those in the group without osteoporosis, the instrumental activities of daily life (IADL) scores were significantly lower (p=0.001 and p=0.007, respectively). No significant differences were observed in Mini-Nutritional Assessment, Mini-Mental State Examination, and Geriatric Depression Scale scores (p=0.598, p=0.898, and p=0.287, respectively). Conclusion: This is the first study to examine the relationship between osteoporosis and several geriatric syndromes, as well as the relationship between osteoporosis and serum MMP, TIMP values, and MMP/TIMP ratios in geriatric patients. Our results showed that osteoporosis causes dependency in both BADLs and IADLs, and that the MMP2/TIMP2 and MMP9/TIMP1 ratios provided no additional benefit in demonstrating bone resorption in geriatric osteoporosis.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0