지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,129 - 1,137 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Local treatment has become a treatment option for patients with de novo metastatic hormone-sensitive prostate cancer(mHSPC). Subgroup analyses based on a history of cerebrovascular disease (CVD) were performed to evaluate the impact thereofon overall survival (OS) after local treatment. Materials and Methods: A retrospective analysis was performed for 879 patients with de novo mHSPC between August 2003 andNovember 2016. Patients were stratified according to prior CVD history and the type of initial treatment: androgen-deprivation therapy(ADT) alone versus local treatment consisting of radical prostatectomy (RP) or radiation therapy (RT) with ADT, with or withoutmetastasis-directed therapy. The primary outcome was OS assessed by Kaplan-Meier analysis and Cox-regression models. Results: Of 879 patients, 660 (75.1%) men underwent ADT alone, and 219 (24.9%) men underwent RP or RT with ADT, with or withoutmetastasis-directed therapy. The median follow-up was 38 months. Multivariable analysis showed CVD history to be associatedwith a higher risk of overall mortality (p=0.001). In the overall cohort and in patients without a history of CVD, patients whounderwent local treatment exhibited higher OS than men who received ADT alone (all p<0.001). However, the survival benefit conferredby local treatment was not seen in patients with a history of CVD (p=0.324). OS was comparable between patients who receivedRP and RT (p=0.521). Conclusion: Local treatment with or without metastasis-directed therapy may provide OS advantages for mHSPC patients withouta history of CVD. Further prospective studies are needed to address these important concerns.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Hellman S / 1995 / Oligometastases / J Clin Oncol 13:8~10
Uppal A / 2014 / Towards a molecular basis of oligometastatic disease : potential role of micro-RNAs / Clin Exp Metastasis 31:735~748
박재원 / 2018 / Impact of Early Salvage Androgen Deprivation Therapy in Localized Prostate Cancer after Radical Prostatectomy: A Propensity Score Matched Analysis / Yonsei Medical Journal 59(5):580~587
Sharifi N / 2005 / Androgen deprivation therapy for prostate cancer / JAMA 294:238~244
Mohler JL / 2019 / Prostate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in oncology / J Natl Compr Canc Netw 17:479~505
Uppal A / 2014 / Towards a molecular basis of oligometastatic disease : potential role of micro-RNAs / Clin Exp Metastasis 31:735~748
박재원 / 2018 / Impact of Early Salvage Androgen Deprivation Therapy in Localized Prostate Cancer after Radical Prostatectomy: A Propensity Score Matched Analysis / Yonsei Medical Journal 59(5):580~587
Sharifi N / 2005 / Androgen deprivation therapy for prostate cancer / JAMA 294:238~244
Mohler JL / 2019 / Prostate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in oncology / J Natl Compr Canc Netw 17:479~505
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Impact of Cardiovascular Diseases on Mortality in Gastric Cancer Patients with Preexisting Chronic Disease
Yonsei Medical Journal
2022 .11
-
성인 조현병 환자의 심혈관질환 동반에 따른 입원 위험 및 질병 비용: 후향적 단면연구
보건의료기술평가
2023 .06
-
Multimodal therapy for locally advanced prostate cancer: the roles of radiotherapy, androgen deprivation therapy, and their combination
Radiation oncology journal : ROJ
2017 .01
-
Metabolic Syndrome Causes Cardiovascular Disease under Stable Statin Medication
지질·동맥경화학회지
2017 .12
-
Clinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study
Clinical Hypertension
2015 .01
-
National trend of the treatment for chronic venous diseases in Korea between 2010 and 2020
Annals of Surgical Treatment and Research
2023 .01
-
Decomposition of Socioeconomic Inequality in Cardiovascular Disease Prevalence in the Adult Population: A Cohort-based Cross-sectional Study in Northwest Iran
예방의학회지
2022 .05
-
The association between the severity of erectile dysfunction and left ventricular diastolic dysfunction in patients with and without cardiovascular disease
Investigative and Clinical Urology
2024 .03
-
Optimal PSA Threshold for Androgen-Deprivation Therapy in Patients with Prostate Cancer following Radical Prostatectomy and Adjuvant Radiation Therapy
Yonsei Medical Journal
2020 .01
-
Exploring the crosstalk between adipose tissue and the cardiovascular system
Korean Circulation Journal
2017 .01
-
Sex differences in the relationship between depression and cardiovascular disease risk: a nationwide study in Korea
Osong Public Health and Research Persptectives
2021 .01
-
Cancer-Specific Mortality among Korean Men with Localized or Locally Advanced Prostate Cancer Treated with Radical Prostatectomy Versus Radiotherapy: A Multi-center Study Using Propensity Scoring and Competing Risk Regression Analyses
Cancer Research and Treatment
2018 .01
-
Association of Body Composition with Long-Term Survival in Non-metastatic Rectal Cancer Patients
Cancer Research and Treatment
2020 .01
-
Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes
Diabetes and Metabolism Journal
2015 .01
-
Treatment Outcomes of Brain metastasis from Papillary Thyroid Cancer
대한 두경부 종양 학술지
2018 .01
-
Changing Patterns of Primary Treatment in Korean Men with Prostate Cancer Over 10 Years: A Nationwide Population Based Study
Cancer Research and Treatment
2016 .01
-
Prognostic Scoring Index for Patients with Metastatic Pancreatic Adenocarcinoma
Cancer Research and Treatment
2016 .01
-
Trends in Regional Disparity in Cardiovascular Mortality in Korea, 1983–2019
Korean Circulation Journal
2022 .11
-
Adjuvant Treatment Modalities, Prognostic Predictors and Outcomes of Uterine Carcinosarcomas
Cancer Research and Treatment
2015 .01
-
Pre-Existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk
Diabetes and Metabolism Journal
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0