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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 670 - 685 (16page)
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초록· 키워드
오류제보하기
Obesity is a clinical entity critically involved in the development and progression of cardiovascular disease (CVD), which is characterised by variable expansion of adipose tissue (AT) mass across the body as well as by phenotypic alterations in AT. AT is able to secrete a diverse spectrum of biologically active substances called adipocytokines, which reach the cardiovascular system via both endocrine and paracrine routes, potentially regulating a variety of physiological and pathophysiological responses in the vasculature and heart. Such responses include regulation of inflammation and oxidative stress as well as cell proliferation, migration and hypertrophy. Furthermore, clinical observations such as the “obesity paradox,” namely the fact that moderately obese patients with CVD have favourable clinical outcome, strongly indicate that the biological “quality” of AT may be far more crucial than its overall mass in the regulation of CVD pathogenesis. In this work, we describe the anatomical and biological diversity of AT in health and metabolic disease; we next explore its association with CVD and, importantly, novel evidence for its dynamic crosstalk with the cardiovascular system, which could regulate CVD pathogenesis.
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참고문헌 (110)
참고문헌 신청
Hubert HB / 1983 / Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study / Circulation 67:968~977
Sowers JR. / 2003 / Obesity as a cardiovascular risk factor / Am J Med 115(Suppl 8A):37S~41S
Britton KA / 2013 / Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality / J Am Coll Cardiol 62:921~925
Greif M / 2009 / Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis / Arterioscler Thromb Vasc Biol 29:781~786
McQuaid SE / 2010 / Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids / Diabetes 59:2465~2473
Sowers JR. / 2003 / Obesity as a cardiovascular risk factor / Am J Med 115(Suppl 8A):37S~41S
Britton KA / 2013 / Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality / J Am Coll Cardiol 62:921~925
Greif M / 2009 / Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis / Arterioscler Thromb Vasc Biol 29:781~786
McQuaid SE / 2010 / Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids / Diabetes 59:2465~2473
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