Treatment Outcomes of Brain metastasis from Papillary Thyroid Cancer

배현우; 김석모; 김수영; 장호진; 김법우; 이용상; 장항석; 박정수

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자료유형: 학술저널

저자정보: 배현우 (연세대학교 강남세브란스병원 갑상선암센터) 김석모 (연세대학교 강남세브란스병원 갑상선암센터) 김수영 (연세대학교 강남세브란스병원 갑상선암센터) 장호진 (연세대학교 강남세브란스병원 갑상선암센터) 김법우 (연세대학교 강남세브란스병원 갑상선암센터) 이용상 (연세대학교 강남세브란스병원 갑상선암센터) 장항석 (연세대학교 강남세브란스병원 갑상선암센터) 박정수 (연세대학교 강남세브란스병원 갑상선암센터)

저널정보: 대한두경부종양학회 대한 두경부 종양 학술지 대한 두경부 종양 학술지 제34권 제1호

발행연도: 2018.1

수록면: 9 - 13 (5page)

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Background/Objectives: Brain metastasis (BM) is a rare form of distant metastasis with papillary thyroid cancer (PTC). Patients with BM of PTC carry a poor prognosis. The aim of this study was to contribute to the understanding of this disease by analyzing patients with BM of PTC. Materials & Methods: Between March 2003 and December 2013, the patient database was conducted to identify thyroid cancer patients treated. Among the 22,758 thyroid cancer patients, 14 (0.06 %) were identified to have metastasis to the brain during follow-up. The medical records of 14 patients with BM were retrospectively reviewed, focusing on the following: patient characteristics, synchronous or previous distant metastasis, treatments including whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS) and surgery, and characteristics on radiologic findings, time interval between first diagnosis of primary thyroid cancer and BM and survival after BM. Results: The mean age at initial diagnosis and BM were $50.9{\pm}15.8years$ and $61.3{\pm}12.7years$. The mean duration between initial diagnosis and BM was $10.4{\pm}7.9years$. Patients were treated with varied combinations of surgery, SRS and WBRT except 4 patients who had refused treatment. The median overall survival (OS) time after BM diagnosis was 10 months (range 1 - 19). Patients receiving treatment (WBRT and/or surgery, SRS) had a significant longer median OS of 16.5 months in comparison to 3.5 months for those treated without treatment. (p = 0.005) Conclusion: Patients who received aggressive treatment had a longer OS than those with only supportive care. Treatment such as surgery, SRS and WBRT should be considered in patients with BM.

#Brain metastasis #Thyroid cancer #Surgery #Radiotherapy #Survival

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