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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 169 - 176 (8page)
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Purpose: To evaluate whether mild chemical irritation of the bladder in neonatal rats is associated with persistent vanilloid receptor transient receptor potential vanilloid subfamily 1 (TRPV1) activity in adult rats. Methods: Female Sprague-Dawley rats were used. Ten-day-old rat pups underwent bladder sensitization via intravesical infusion of 0.2% acetic acid in saline with or without prior bladder desensitization with capsaicin. After 8 weeks, 3 groups of rats (control [group 1], bladder sensitization [group 2], and bladder desensitization [group 3]) underwent cystometry. Inflammation of bladder tissue and the expression of TRPV1 in bladder tissue and dorsal root ganglia (DRG) were also evaluated. Results: The bladder sensitization group showed more frequent voiding contractions. TRPV1 expression in adult bladder tissue was elevated in group 2. TRPV1 mRNA levels in the bladder and DRG were significantly higher in group 2 than in group 1. Moreover, group 2 had significantly more DRG neurons (identified by uptake of the retrograde label Fast Blue) that exhibited TRPV1 immunoreactivity. Conclusions: We found a significant association between neonatal bladder sensitization and persistent TRPV1 activity in adult rats. This is the first study to focus on the underlying pathogenesis of bladder overactivity from childhood to adulthood. Our findings could lead to the development of new strategies for the treatment and prevention of adult urinary symptoms arising from childhood urinary tract dysfunction.
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참고문헌 (25)
참고문헌 신청
Fitzgerald MP / 2006 / Childhood urinary symptoms predict adult overactive bladder symptoms / J Urol 175(3 Pt 1):989~993
Held PJ / 1990 / Interstitial cystitis / Springer :29~48
Hannestad YS / 2004 / Familial risk of urinary incontinence in women: population based cross sectional study / BMJ 329:889~891
Rohr G / 2004 / Genetic and environmental influences on urinary incontinence: a Danish populationbased twin study of middle-aged and elderly women / Acta Obstet Gynecol Scand 83:978~982
Birder LA / 2001 / Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells / Proc Natl Acad Sci U S A 98:13396~13401
Held PJ / 1990 / Interstitial cystitis / Springer :29~48
Hannestad YS / 2004 / Familial risk of urinary incontinence in women: population based cross sectional study / BMJ 329:889~891
Rohr G / 2004 / Genetic and environmental influences on urinary incontinence: a Danish populationbased twin study of middle-aged and elderly women / Acta Obstet Gynecol Scand 83:978~982
Birder LA / 2001 / Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells / Proc Natl Acad Sci U S A 98:13396~13401
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