Immediate Breast Reconstruction vs. Mastectomy Alone in Locally Advanced Breast Cancer; Local Recurrence and Distant Recurrence

Youngjin Kim; Eun-Shin Lee; Jong Ho Cheun; Jigwang Jung; Han-Byoel Lee; Hyeong-Gon Moon; Dong-Young Noh; Wonshik Han

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자료유형: 학술저널

저자정보: Youngjin Kim Eun-Shin Lee Jong Ho Cheun Jigwang Jung Han-Byoel Lee Hyeong-Gon Moon Dong-Young Noh Wonshik Han

저널정보: 한국유방암학회 Journal of Breast Disease Journal of Breast Disease 제7권 제2호

발행연도: 2019.1

수록면: 89 - 96 (8page)

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Purpose: The oncologic safety of immediate breast reconstruction (IBR) has been demonstrated. However, the outcome of IBR for locally advanced breast cancer (LABC) is still under debate. We compared the survival outcome of LABC patients who underwent IBR vs. mastectomy alone. Methods: We retrospectively analyzed a total of 248 patients with stage III breast cancer who were treated with mastectomy between 2004 and 2015. The study subjects were divided into 2 groups: patients who received IBR (n=77) or mastectomy alone (MA) (n=171). We compared disease-free survival (DFS) of both groups. Results: Median follow-up duration was 49 months and the mean age of patients was 49 years. Patients in the IBR group were significantly younger and had lower body mass index (BMI) than those in the MA group. In a univariate analysis, IBR group showed better DFS than the MA group (DFS 81.3 months vs. 49.8 months, p<0.001). There was no delay in adjuvant treatment in the IBR group. In a multivariate analysis, IBR was associated with better DFS (hazard ratio (HR) for recurrence: 0.37, 95% CI 0.20–0.69, p=0.002) when adjusted for potential prognostic factors. In a subgroup analysis performed according to disease stage (IIIA and IIIB/IIIC), DFS was significantly better in IBR than MA group in both stage subgroups (p<0.001). Conclusion: We demonstrated that patients who underwent IBR showed better DFS outcome compared with patients who underwent mastectomy alone. Our results can help surgeons to determine if IBR is an option in patients with LABC.

참고문헌 (36)

참고문헌 신청

Yang RL / 2013 / Trends in immediate breast reconstruction across insurance groups after enactment of breast cancer legislation / Cancer 119:2462~2468

Reuben BC / 2009 / Recent trends and predictors in immediate breast reconstruction after mastectomy in the United States / Am J Surg 198:237~243

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Gieni M / 2012 / Local breast cancer recurrence after mastectomy and immediate breast reconstruction for invasive cancer: A meta-analysis / Breast 21:230~236

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