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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 293 - 305 (13page)
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초록· 키워드
오류제보하기
The difference in the breeding programs and population history may have diversely shaped the genomes of Korean native cattle breeds. In the absence of phenotypic data, comparisons of breeds that have been subjected to different selective pressures can aid to identify genomic regions and genes controlling qualitative and complex traits. In this study to decipher genetic variation and identify evidence of divergent selection, 3 Korean cattle breeds were genotyped using the recently developed high-density GeneSeek Genomic Profiler F250 (GGP-F250) array. The three Korean cattle breeds clustered according to their coat color phenotypes and breeding programs. The Heugu breed reliably showed smaller effective population size at all generations considered. Across the autosomal chromosomes, 113 and 83 annotated genes were identified from Hanwoo-Chikso and Hanwoo-Heugu comparisons, respectively of which 16 genes were shared between the two pairwise comparisons. The most important signals of selection were detected on bovine chromosomes 14 (24.39–25.13 Mb) and 18 (13.34–15.07 Mb), containing genes related to body size, and coat color (XKR4, LYN, PLAG1, SDR16C5, TMEM68, CDH15, MC1R, and GALNS). Some of the candidate genes are also associated with meat quality traits (ACSF3, EIF2B1, BANP, APCDD1, and GALM) and harbor quantitative trait locus (QTL) for beef production traits. Further functional analysis revealed that the candidate genes (DBI, ACSF3, HINT2, GBA2, AGPAT5, SCAP, ELP6, APOB, and RBL1) were involved in gene ontology (GO) terms relevant to meat quality including fatty acid oxidation, biosynthesis, and lipid storage. Candidate genes previously known to affect beef production and quality traits could be used in the beef cattle selection strategies.
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등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
이승환 / 2014 / Hanwoo cattle: origin, domestication, breeding strategies and genomic selection / 한국축산학회지 56(1):1~8
Hailu Dadi / 2014 / Inter- and intra-population genetic divergence of East Asian cattle populations: focusing on Korean cattle / Genes & Genomics 36(3):261~265
Decker JE / 2014 / Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle / PLoS Genet 10:e1004254
하이루 / 2012 / Effect of Population Reduction on mtDNA Diversity and Demographic History of Korean Cattle Populations / Animal Bioscience 25(9):1223~1228
서상원 / 2014 / Assessment of Genetic Diversity, Relationships and Structure among Korean Native Cattle Breeds Using Microsatellite Markers / Animal Bioscience 27(11):1548~1553
Hailu Dadi / 2014 / Inter- and intra-population genetic divergence of East Asian cattle populations: focusing on Korean cattle / Genes & Genomics 36(3):261~265
Decker JE / 2014 / Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle / PLoS Genet 10:e1004254
하이루 / 2012 / Effect of Population Reduction on mtDNA Diversity and Demographic History of Korean Cattle Populations / Animal Bioscience 25(9):1223~1228
서상원 / 2014 / Assessment of Genetic Diversity, Relationships and Structure among Korean Native Cattle Breeds Using Microsatellite Markers / Animal Bioscience 27(11):1548~1553
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