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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 103 - 109 (7page)
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Growing evidence suggests that mitochondrial reactive oxygen species (ROS) are involved in various pain states.
This study was performed to investigate whether ROS-induced changes in neuronal excitability in trigeminal subnucleus caudalis are related to ROS generation in mitochondria. Confocal scanning laser microscopy was used to measure ROS-induced fluorescence intensity in live rat trigeminal caudalis slices. The ROS level increased during the perfusion of malate, a mitochondrial substrate, after loading of 2′,7′-dichlorofluorescin diacetate (H2DCF-DA), an indicator of the intracellular ROS; the ROS level recovered to the control condition after washout. When pre-treated with phenyl N-tert-butylnitrone (PBN) and 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (TEMPOL), malate-induced increase of ROS level was suppressed. To identify the direct relation between elevated ROS levels and mitochondria, we applied the malate after double-loading of H2DCF-DA and chloromethyl-X-rosamine (CMXRos; MitoTracker Red), which is a mitochondriaspecific fluorescent probe. As a result, increase of both intracellular ROS and mitochondrial ROS were observed simultaneously. This study demonstrated that elevated ROS in trigeminal subnucleus caudalis neuron can be induced through mitochondrial-ROS pathway, primarily by the leakage of ROS from the mitochondrial electron transport chain.
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참고문헌 (24)
참고문헌 신청
Baran CP / 2004 / The role of ROS and RNA in regulating life and death of blood monocytes / Curr Pharm 10 : 855 ~ 866
Bubici C / 2006 / The NF-kappaB-mediated control of ROS and JNK signaling / Histol Histopathol 21 : 69 ~ 80
David F. Stowe / 2009 / Mitochondrial Reactive Oxygen Species Production in Excitable Cells: Modulators of Mitochondrial and Cell Function / Antioxidants & Redox Signali
Djordjevic VB / 2004 / Free radicals in cell biology / Int Rev Cytol 237 : 57 ~ 89
Dubner R / 1983 / Spinal and trigeminal mechanisms of nociception / Annu Rev Neurosci 6 : 381 ~ 418
Bubici C / 2006 / The NF-kappaB-mediated control of ROS and JNK signaling / Histol Histopathol 21 : 69 ~ 80
David F. Stowe / 2009 / Mitochondrial Reactive Oxygen Species Production in Excitable Cells: Modulators of Mitochondrial and Cell Function / Antioxidants & Redox Signali
Djordjevic VB / 2004 / Free radicals in cell biology / Int Rev Cytol 237 : 57 ~ 89
Dubner R / 1983 / Spinal and trigeminal mechanisms of nociception / Annu Rev Neurosci 6 : 381 ~ 418
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