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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제3호
- 발행연도
- 2020.1
- 수록면
- 249 - 257 (9page)
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The aim of the present study was to investigate the pathophysiological etiology of osteoarthritis that is mediated by the apoptosis of chondrocytes exposed to 25-hydroxycholesterol (25-HC), an oxysterol synthesized by the expression of cholesterol-25-hydroxylase (CH25H) under inflammatory conditions. Interleukin-1β induced the apoptosis of chondrocytes in a dose- dependent manner. Furthermore, the production of 25-HC increased in the chondrocytes treated with interleukin-1β through the expression of CH25H. 25-HC decreased the viability of chondrocytes. Chondrocytes with condensed nucleus and apoptotic populations increased by 25- HC. Moreover, the activity and expression of caspase-3 were increased by the death ligand-mediated extrinsic and mitochondria-dependent intrinsic apoptotic pathways in the chondrocytes treated with 25-HC. Finally, 25-HC induced not only caspasedependent apoptosis, but also induced proteoglycan loss in articular cartilage ex vivo cultured rat knee joints. These data indicate that 25-HC may act as a metabolic pathophysiological factor in osteoarthritis that is mediated by progressive chondrocyte death in the articular cartilage with inflammatory condition.
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참고문헌 (20)
참고문헌 신청
Cross M / 2014 / The global burden of hip and knee osteoarthritis : estimates from the global burden of disease 2010 study / Ann Rheum Dis 73:1323~1330
Oliviero F / 2012 / A comparative study of serum and synovial fluid lipoprotein levels in patients with various arthritides / Clin Chim Acta 413:303~307
Kostopoulou F / 2015 / MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes / Arthritis Res Ther 17:42
Choi WS / 2019 / The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis / Nature 566:254~258
Olivier E / 2017 / 25-Hydroxycholesterol induces both P2X7-dependent pyroptosis and caspasedependent apoptosis in human skin model : new insights into degenerative pathways / Chem Phys Lipids 207(Pt B):171~178
Oliviero F / 2012 / A comparative study of serum and synovial fluid lipoprotein levels in patients with various arthritides / Clin Chim Acta 413:303~307
Kostopoulou F / 2015 / MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes / Arthritis Res Ther 17:42
Choi WS / 2019 / The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis / Nature 566:254~258
Olivier E / 2017 / 25-Hydroxycholesterol induces both P2X7-dependent pyroptosis and caspasedependent apoptosis in human skin model : new insights into degenerative pathways / Chem Phys Lipids 207(Pt B):171~178
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