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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제6호
- 발행연도
- 2019.1
- 수록면
- 427 - 448 (22page)
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Nociceptin/orphanin FQ (N/OFQ) and its receptor, nociceptin opioid peptide (NOP) receptor, are localized in brain areas implicated in depression including the amygdala, bed nucleus of the stria terminalis, habenula, and monoaminergic nuclei in the brain stem. N/OFQ inhibits neuronal excitability of monoaminergic neurons and monoamine release from their terminals by activation of G protein-coupled inwardly rectifying K+ channels and inhibition of voltage sensitive calcium channels, respectively. Therefore, NOP receptor antagonists have been proposed as a potential antidepressant. Indeed, mounting evidence shows that NOP receptor antagonists have antidepressant-like effects in various preclinical animal models of depression, and recent clinical studies again confirmed the idea that blockade of NOP receptor signaling could provide a novel strategy for the treatment of depression. In this review, we describe the pharmacological effects of N/OFQ in relation to depression and explore the possible mechanism of NOP receptor antagonists as potential antidepressants
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참고문헌 (168)
참고문헌 신청
Lane RM / 2015 / Antidepressant drug development : Focus on triple monoamine reuptake inhibition / J Psychopharmacol 29:526~544
Skolnick P / 2006 / Preclinical and clinical pharmacology of DOV 216, 303, a"triple"reuptake inhibitor / CNS Drug Rev 12:123~134
Chen Z / 2008 / Designing new treatments for depression and anxiety / IDrugs 11:189~197
Witkin JM / 2016 / Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors / Pharmacol Res Perspect 4:e00275
Post A / 2016 / A selective nociceptin receptor antagonist to treat depression : evidence from preclinical and clinical studies / Neuropsychopharmacology 41:1803~1812
Skolnick P / 2006 / Preclinical and clinical pharmacology of DOV 216, 303, a"triple"reuptake inhibitor / CNS Drug Rev 12:123~134
Chen Z / 2008 / Designing new treatments for depression and anxiety / IDrugs 11:189~197
Witkin JM / 2016 / Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors / Pharmacol Res Perspect 4:e00275
Post A / 2016 / A selective nociceptin receptor antagonist to treat depression : evidence from preclinical and clinical studies / Neuropsychopharmacology 41:1803~1812
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