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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제4호
- 발행연도
- 2016.7
- 수록면
- 407 - 414 (8page)
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초록· 키워드
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This study was performed to investigate whether the spinal cho-linergic and serotonergic analgesic systems mediate the relieving effect of elec-troacupuncture (EA) on oxaliplatin-induced neuropathic cold allodynia in rats. The cold allodynia induced by an oxaliplatin injection (6 mg/kg, i.p.) was evaluated by immersing the rat’s tail into cold water (4oC) and measuring the withdrawal latency. EA stimulation (2 Hz, 0.3-ms pulse duration, 0.2~0.3 mA) at the acupoint ST36, GV3, or LI11 all showed a significant anti-allodynic effect, which was stronger at ST36. The analgesic effect of EA at ST36 was blocked by intraperitoneal injection of muscarinic acetylcholine receptor antagonist (atropine, 1 mg/kg), but not by nicotinic (mecamylamine, 2 mg/kg) receptor antagonist. Furthermore, intrathecal administration of M2(methoctramine, 10μg) and M3 (4-DAMP, 10μg) receptor antagonist, but not M1 (pirenzepine, 10μg) receptor antagonist, blocked the effect. Also, spinal administration of 5-HT3 (MDL-72222, 12μg) receptor antagonist, but not 5-HT1A (NAN-190, 15μg) or 5-HT2A (ketanserin, 30μg) receptor antagonist, prevented the anti-allodynic effect of EA. These results suggest that EA may have a signi? cant analgesic action against oxaliplatin-induced neuropathic pain, which is mediated by spinal cholinergic (M2, M3) and serotonergic (5-HT3) receptors.
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참고문헌 (45)
참고문헌 신청
Goldberg RM / 2004 / A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer / J Clin Oncol 22:23~30
Arany I / 2003 / Cisplatin nephrotoxicity / Semin Nephrol 23:460~464
Desoize B / 2002 / Particular aspects of platinum compounds used at present in cancer treatment / Crit Rev Oncol Hematol 42:317~325
Pasetto LM / 2006 / Oxaliplatinrelated neurotoxicity : how and why? / Crit Rev Oncol Hematol 59:159~168
Gamelin E / 2002 / Clinical aspects and molecular basis of oxaliplatin neurotoxicity : current management and development of preventive measures / Semin Oncol 29(5Suppl 15):21~33
Arany I / 2003 / Cisplatin nephrotoxicity / Semin Nephrol 23:460~464
Desoize B / 2002 / Particular aspects of platinum compounds used at present in cancer treatment / Crit Rev Oncol Hematol 42:317~325
Pasetto LM / 2006 / Oxaliplatinrelated neurotoxicity : how and why? / Crit Rev Oncol Hematol 59:159~168
Gamelin E / 2002 / Clinical aspects and molecular basis of oxaliplatin neurotoxicity : current management and development of preventive measures / Semin Oncol 29(5Suppl 15):21~33
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