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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 412 - 416 (5page)
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초록· 키워드
오류제보하기
Objective The objective of this study was to assess the effectiveness and safety of atomoxetine in Korean children and adolescents with epilepsy. Methods We retrospectively reviewed the electronic medical records of 105 children and adolescents with epilepsy treated with atomoxetine. Effectiveness was measured with the Clinical Global Impressions-Severity (CGI-S) and/or Clinical Global Impressions-Improvement (CGI-I) scales at baseline, and after 4 and 12 weeks. We defined response to atomoxetine as a CGI-I score less than three at week 12. Safety was evaluated at each visit, based on clinical assessment by a child and adolescent psychiatrist and reports from participants or their caregivers. Results In total participants (n=105), 33 (31.4%) showed a response to treatment: a significant decrease in CGI-S scale score was observed over 12 weeks of atomoxetine treatment. The most common adverse event (AE) was decreased appetite (n=16, 15.2%), and life-threatening AEs were not observed. Seizure aggravation due to atomoxetine was observed in 7.6% (n=8) of total participants, and one of them discontinued atomoxetine. Conclusion Our results provide preliminary evidence of the effectiveness and safety of atomoxetine in children and adolescents with epilepsy.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
American Psychiatric Association / 2013 / Diagnostic and Statistical Manual for Mental Disorder 5(DSM-5) / American Psychiatric Association
Barkely RA / 2015 / Attention Deficit Hyperactivity Disorder : A Handbook for Diagnosis and Treatment / The Guilford Press
Volk HE / 2005 / A systematic evaluation of ADHD and comorbid psychopathology in a population-based twin sample / J Am Acad Child Adolesc Psychiatry 44:768~775
Dunn DW / 2003 / ADHD and epilepsy in childhood / Dev Med Child Neurol 45:50~54
Dunn DW / 2004 / Differential diagnosis and treatment of psychiatric disorders in children and adolescents with epilepsy / Epilepsy Behav 5(Suppl 3):S10~S17
Barkely RA / 2015 / Attention Deficit Hyperactivity Disorder : A Handbook for Diagnosis and Treatment / The Guilford Press
Volk HE / 2005 / A systematic evaluation of ADHD and comorbid psychopathology in a population-based twin sample / J Am Acad Child Adolesc Psychiatry 44:768~775
Dunn DW / 2003 / ADHD and epilepsy in childhood / Dev Med Child Neurol 45:50~54
Dunn DW / 2004 / Differential diagnosis and treatment of psychiatric disorders in children and adolescents with epilepsy / Epilepsy Behav 5(Suppl 3):S10~S17
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