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논문 기본 정보

자료유형
학술저널
저자정보
방수영 (을지대학교) 황준원 (강원대학교) 곽영숙 (제주대학교) 정유숙 (성균관대학교) 이소영 (순천향대학교) 김봉석 (인제대학교) 손석한 (연세 정신과의원) 정운선 (경북대학교병원) 양재원 (KAIST Clinic) 홍민하 (서남대학교) 반건호 (경희대학교) 최형윤 (질병관리본부) 오인환 (경희대학교) 이연정 (순천향대학교)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.31 No.8
발행연도
2016.1
수록면
1,284 - 1,291 (8page)

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We evaluated the differences in utilization patterns including persistence and adherence among medications in children and adolescents with attention deficit hyperactivity disorder (ADHD). The current study was performed using data from the Korean Health Insurance Review and Assessment claims database from January 1, 2009 to December 31, 2013. Our study sample consisted of 10,343 children and adolescents with ADHD who were not given their newly prescribed medication in 360 days before the initial claim in 2010. Data were followed up from the initiation of treatment with ADHD medications in 2010 to December 31, 2013. Discontinuation rates for 4 ADHD medications in our sample ranged from 97.7% for immediate-release methylphenidate to 99.4% for atomoxetine using refill gap more than 30 days and from 56.7% for immediate-release methylphenidate to 62.3% for extended-release methylphenidate using refill gap more than 60 days. In the number of discontinued, we found significant differences among medications using refill gap more than 30 days. Among 4 ADHD medications, extended-release methylphenidate and atomoxetine had more days than immediate-release methylphenidate and osmoticcontrolled oral delivery system methylphenidate. In logistic regression analyses, extendedrelease methylphenidate, osmotic-controlled oral delivery system methylphenidate, and atomoxetine showed less discontinuation compared to immediate-release methylphenidate group when a refill gap more than 30 days was used. In logistic regression analysis of adherence, we could not find any differences among 4 medication types. We suggest that the utilization patterns should be assessed regularly in order to improve future outcomes in children and adolescents with ADHD.

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