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자료유형
학술저널
저자정보
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제63권 제4호
발행연도
2020.1
수록면
514 - 520 (7page)

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ObjectiveThe aim of the present study was to compare the efficacy of vaginal isoniazid (isonicotinic acid hydrazide [INH]) andvaginal misoprostol in cervical ripening before hysteroscopic surgery. MethodsThis randomized controlled trial included patients scheduled for hysteroscopic surgery during April 2016 and June2017. The inclusion criteria were as follows: postmenopausal women or those at premenopausal age who had nothad a vaginal delivery and candidate for diagnostic or operative hysteroscopy with closed cervix before intervention. The INH group (intervention group) received 900 mg of vaginal isoniazid (three 300-mg pills) 6–8 hours beforehysteroscopic surgery. The misoprostol group (control group) received 400 micrograms of vaginal misoprostol 6–8hours before hysteroscopic surgery. Finally, the efficacy of the 2 agents was comparatively analyzed. ResultsBaseline characteristics were comparable between the groups. In 67 cases in the INH group (95%) and 45 in themisoprostol group (50%), hysteroscopic entry was successful without additional mechanical dilation, and thisdifference was statistically significant (P=0.001). The odds ratio (OR) obtained in this study was 0.57 for both INH andmisoprostol groups (OR, 0.57; 95% confidence interval, 0.43–0.75). Further, 19 cases in the INH group vs. 45 cases inthe misoprostol group did not respond to the intervention, indicating statistically significance (P=0.001). ConclusionVaginal INH is more effective than misoprostol in cervical ripening before hysteroscopic surgery and can be a goodalternative to misoprostol.

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