지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,034 - 1,041 (8page)
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Purpose: Isoniazid (INH) mono-resistant tuberculosis (Hr-TB) is a highly prevalent type of drug-resistant TB, possibly associatedwith unfavorable treatment outcomes. However, definitive guidelines on an optimal treatment regimen and duration for Hr-TBare currently under discussion. We evaluated the characteristics and treatment outcomes of Hr-TB patients. Materials and Methods: We retrospectively reviewed the medical records of Hr-TB patients treated at a South Korean tertiary referralhospital from January 2005 to December 2018. Results: We included 195 Hr-TB patients. 113 (57.9%) were male, and the median age was 56.6 [interquartile range, 40.2?68.6]years. Mutations in katG were the most frequent [54 (56.3%)], followed by those in the inhA [34 (35.4%)]. Favorable and unfavorableoutcomes were noted in 164 (84.1%) and 31 (15.9%) patients, respectively. Smoking history [odds ratio (OR)=5.606, 95% confidenceinterval (CI): 1.695?18.543, p=0.005], low albumin level (OR=0.246, 95% CI: 0.104?0.578, p=0.001), and positive acid-fastbacilli culture at 2 months (OR=7.853, 95% CI: 1.246?49.506, p=0.028) were associated with unfavorable outcomes. Conclusion: A tailored strategy targeting high-risk patients is imperative for improved treatment outcomes. Further research onthe rapid and accurate detection of resistance to INH and other companion drugs is warranted.
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참고문헌 (30)
참고문헌 신청
Berning S / 1999 / Antimicrobial therapy and vaccines / Williams and Wilkins :654~662
World Health Organization / 2018 / WHO treatment guidelines for isoniazid-resistant tuberculosis : supplement to the WHO treatment guidelines for drug-resistant tuberculosis
Cattamanchi A / 2009 / Clinical characteristics and treatment outcomes of patients with isoniazid-monoresistant tuberculosis / Clin Infect Dis 48:179~185
Bang D / 2010 / Isoniazid-resistant tuberculosis in Denmark : mutations, transmission and treatment outcome / J Infect 60:452~457
Smith SE / 2012 / Global isoniazid resistance patterns in rifampin-resistant and rifampin-susceptible tuberculosis / Int J Tuberc Lung Dis 16:203~205
World Health Organization / 2018 / WHO treatment guidelines for isoniazid-resistant tuberculosis : supplement to the WHO treatment guidelines for drug-resistant tuberculosis
Cattamanchi A / 2009 / Clinical characteristics and treatment outcomes of patients with isoniazid-monoresistant tuberculosis / Clin Infect Dis 48:179~185
Bang D / 2010 / Isoniazid-resistant tuberculosis in Denmark : mutations, transmission and treatment outcome / J Infect 60:452~457
Smith SE / 2012 / Global isoniazid resistance patterns in rifampin-resistant and rifampin-susceptible tuberculosis / Int J Tuberc Lung Dis 16:203~205
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