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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 220 - 226 (7page)
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초록· 키워드
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ObjectiveTo assess the efficacy and safety of vaginal misoprostol after a pretreatment with vaginal estradiol to facilitate the hysteroscopic surgery in postmenopausal women.
MethodsIn this observational comparative study, 35 control women (group A) did not receive any pharmacological treatment,26 women (group B) received 25 μg of vaginal estradiol daily for 14 days and 400 μg of vaginal misoprostol 12 hours before hysteroscopic surgery, 32 women (group C) received 400 μg of vaginal misoprostol 12 hours before surgery.
ResultsDemographic data were well balanced and all variables were not significantly different among the three groups. The study showed a significant difference in the preoperative cervical dilatation among the group B (7.09±1.87 mm), the group A (5.82±1.85 mm; B vs. A, P=0.040) and the group C (5.46±2.07 mm; B vs. C, P=0.007). The dilatation was very easy in 73% of women in group B. The pain scoring post surgery was lower in the group B (B vs. A, P=0.001; B vs. C, P=0.077). In a small subgroup of women with suspected cervical stenosis, there were no statistically significant differences among the three groups considered. No complications during and post hysteroscopy were observed.
ConclusionIn postmenopausal women the pretreatment with oestrogen appears to have a crucial role in allowing the effect of misoprostol on cervical ripening. The combination of vaginal estradiol and vaginal misoprostol presents minor side effects and has proved to be effective in obtaining satisfying cervical dilatation thus significantly reducing discomfort for the patient.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Jansen FW / 2000 / Complications of hysteroscopy:a prospective, multicenter study / Obstet Gynecol 96:266~270
Gkrozou F / 2011 / A systematic review and metaanalysis of randomized studies comparing misoprostol versus placebo for cervical ripening prior to hysteroscopy / Eur J Obstet Gynecol Reprod Biol 158:17~23
Selk A / 2011 / Misoprostol in operative hysteroscopy : a systematic review and meta-analysis / Obstet Gynecol 118:941~949
Polyzos NP / 2012 / Misoprostol prior to hysteroscopy in premenopausal and post-menopausal women : a systematic review and meta-analysis / Hum Reprod Update 18:393~404
Ngai SW / 2001 / The use of misoprostol prior to hysteroscopy in postmenopausal women / Hum Reprod 16:1486~1488
Gkrozou F / 2011 / A systematic review and metaanalysis of randomized studies comparing misoprostol versus placebo for cervical ripening prior to hysteroscopy / Eur J Obstet Gynecol Reprod Biol 158:17~23
Selk A / 2011 / Misoprostol in operative hysteroscopy : a systematic review and meta-analysis / Obstet Gynecol 118:941~949
Polyzos NP / 2012 / Misoprostol prior to hysteroscopy in premenopausal and post-menopausal women : a systematic review and meta-analysis / Hum Reprod Update 18:393~404
Ngai SW / 2001 / The use of misoprostol prior to hysteroscopy in postmenopausal women / Hum Reprod 16:1486~1488
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