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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 225 - 230 (6page)
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초록· 키워드
오류제보하기
ObjectiveRecently, strong evidences were obtained on the association between low pregnancy-associated plasma protein-A(PAPP-A) levels in the first trimester and poor outcomes of pregnancy. MethodsThis cross-sectional study was conducted on all pregnant women who were referred to the Obstetrics and GynecologyClinic at Imam Hossein Hospital in Tehran, Iran in 2014. Women were asked to attend clinical examinations andscreening at 11–14 weeks of gestation. ResultsBased on the definition, 14.5% of neonates found to be small for gestational age (SGA). There was a strongassociation between PAPP-A levels and birth weight. The mean PAPP-A level in the mothers of neonates who wereSGA was significantly lower than those without this poor outcome. Based on the receiver operating characteristiccurve analysis, serum PAPP-A level was a main determinant in the prediction of SGA neonates. ConclusionThe serum PAPP-A level at 11–13 weeks of gestation can effectively predict the increased risk for fetal growthretardation. In patients in this study, the best cutoff value for PAPP-A was 0.75 MOM, which signifies that lower levelsof this marker can predict fetal growth restriction with high sensitivity and specificity.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Kagan KO / 2008 / Screening for trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal heart rate, free beta-hCG and pregnancy-associated plasma protein-A / Hum Reprod 23:1968~1975
Kagan KO / 2008 / First-trimester screening for trisomy 21 by free betahuman chorionic gonadotropin and pregnancy-associated plasma protein-A : impact of maternal and pregnancy characteristics / Ultrasound Obstet Gynecol 31:493~502
Ong CY / 2000 / First trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications / BJOG 107:1265~1270
Yaron Y / 2002 / Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome / Prenat Diagn 22:778~782
Smith GC / 2002 / Early pregnancy levels of pregnancyassociated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth / J Clin Endocrinol Metab 87:1762~1767
Kagan KO / 2008 / First-trimester screening for trisomy 21 by free betahuman chorionic gonadotropin and pregnancy-associated plasma protein-A : impact of maternal and pregnancy characteristics / Ultrasound Obstet Gynecol 31:493~502
Ong CY / 2000 / First trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications / BJOG 107:1265~1270
Yaron Y / 2002 / Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome / Prenat Diagn 22:778~782
Smith GC / 2002 / Early pregnancy levels of pregnancyassociated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth / J Clin Endocrinol Metab 87:1762~1767
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