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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: This study was conducted to observe the prevalence of vitamin D deficiency during pregnancy and the effects of maternal 25-hydroxy-vitamin D (25-[OH]D) levels on fetal bone growth. Methods: Five hundred twenty-three Korean pregnant women were randomly recruited and serum 25-(OH)D level was measured. During pregnancy, fetal ultrasonography and serum 25-(OH)D measurements were carried out 3 times in 275 of 523 pregnant women. Fetal biparietal and occipitofrontal diameter, head and abdo minal circumference, and femur and humerus length were measured through fetal ultrasonography. Results: The prevalence of vitamin D deficiency (25-[OH]D<20 ng/mL) based on the 1st serum measurement of 25-(OH)D was 88.9%. There was no association between maternal serum 25-(OH)D level and fetal bone growth. In 275 pregnant women who completed study design, the mean value of 25-(OH)D was 12.97±5.93, 19.12± 9.82, and 19.60±9.98 ng/mL at 12 to 14, 20 to 22, and 32 to 34 weeks of pregnancy, respectively and there was an association between the difference of serum 25-(OH)D level between 12 to 14 and 20 to 22 weeks and growth velocity of fetal biparietal diameter between 20 to 22 and 32 to 34 weeks of pregnancy. Conclusions: This study shows a high prevalence of vitamin D deficiency in Korean pregnant women and the change of serum 25-(OH)D levels is related with the growth of fetal biparietal diameter, however other parameters are not associated with serum 25-(OH)D levels.
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참고문헌 (23)
참고문헌 신청
Bikle D / 2009 / Nonclassic actions of vitamin D / J Clin Endocrinol Metab 94 : 26 ~ 34
Bikle DD / 1986 / Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein / J Clin Endocrinol Metab 6
Bodnar LM / 2007 / Maternal vitamin D deficiency increases the risk of preeclampsia / J Clin Endocrinol Metab 92 : 3517 ~ 3522
Bouillon R / 1981 / Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3. Significance of the free 1,25-dihydroxyvitamin D3 conc
Brannon PM / 2011 / Vitamin D in pregnancy and lactation in humans / Annu Rev Nutr 31 : 89 ~ 115
Bikle DD / 1986 / Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein / J Clin Endocrinol Metab 6
Bodnar LM / 2007 / Maternal vitamin D deficiency increases the risk of preeclampsia / J Clin Endocrinol Metab 92 : 3517 ~ 3522
Bouillon R / 1981 / Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3. Significance of the free 1,25-dihydroxyvitamin D3 conc
Brannon PM / 2011 / Vitamin D in pregnancy and lactation in humans / Annu Rev Nutr 31 : 89 ~ 115
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