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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,509 - 1,516 (8page)
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초록· 키워드
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An elevated serum concentration of uric acid may be associated with an increased risk of acute kidney injury (AKI). The aim of this study was to investigate the impact of preoperative uric acid concentration on the risk of AKI after coronary artery bypass surgery (CABG). Perioperative data were evaluated from patients who underwent CABG. AKI was defined by the AKI Network criteria based on serum creatinine changes within the first 48 hr after CABG. Multivariate logistic regression was utilized to evaluate the association between preoperative uric acid and postoperative AKI. We evaluated changes in C statistic, the net reclassification improvement, and the integrated discrimination improvement to determine whether the addition of preoperative uric acid improved prediction of AKI. Of the 2,185 patients, 787 (36.0%) developed AKI. Preoperative uric acid was significantly associated with postoperative AKI (odds ratio, 1.18; 95% confidence interval, 1.10-1.26; P < 0.001). Adding uric acid levels improved the C statistic and had significant impact on risk reclassification and integrated discrimination for AKI. Preoperative uric acid is related to postoperative AKI and improves the predictive ability of AKI. This finding suggests that preoperative measurement of uric acid may help stratify risks for AKI in in patients undergoing CABG.
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참고문헌 (30)
참고문헌 신청
Dasta JF / 2008 / Costs and outcomes of acute kidney injury(AKI)following cardiac surgery / Nephrol Dial Transplant 23:1970~1974
Hobson CE / 2009 / Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery / Circulation 119:2444~2453
Lee EH / 2012 / Preoperative hypoalbuminemia is a major risk factor for acute kidney injury following off-pump coronary artery bypass surgery / Intensive Care Med 38:1478~1486
Huen SC / 2012 / Predicting acute kidney injury after cardiac surgery : a systematic review / Ann Thorac Surg 93:337~347
Kang DH / 2002 / A role for uric acid in the progression of renal disease / J Am Soc Nephrol 13:2888~2897
Hobson CE / 2009 / Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery / Circulation 119:2444~2453
Lee EH / 2012 / Preoperative hypoalbuminemia is a major risk factor for acute kidney injury following off-pump coronary artery bypass surgery / Intensive Care Med 38:1478~1486
Huen SC / 2012 / Predicting acute kidney injury after cardiac surgery : a systematic review / Ann Thorac Surg 93:337~347
Kang DH / 2002 / A role for uric acid in the progression of renal disease / J Am Soc Nephrol 13:2888~2897
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