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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제6호
- 발행연도
- 2020.1
- 수록면
- 946 - 954 (9page)
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초록· 키워드
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Platycodon grandiflorum root (Platycodi radix) saponins, platycosides, have been used as health supplements and food items for the treatment of respiratory disorders and pulmonary diseases. Deglycosylated saponins have been known to exert stronger biological effects than their glycosylated forms. In the present study, glycosylated platycosides in Platycodi radix extract were biotransformed into deglycosylated 3-O-β-D-glucopyranosyl platycosides, including 3-O-β-Dglucopyranosyl platycodigenin, 3-O-β-D-glucopyranosyl polygalacic acid, and 3-O-β-Dglucopyranosyl platyconic acid, by pectinase from Aspergillus aculeatus. This is the first report on the quantitative enzymatic production of 3-O-β-D-glucopyranosyl platycosides. The chemical structures of 3-O-β-D-glucopyranosyl platycosides were identified with LC/MS. Moreover, the biotransformation pathways of the three types of platycosides in Platycodi radix into 3-O-β-Dglucopyranosyl platycosides were established.
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참고문헌 (21)
참고문헌 신청
Zhao HL / 2008 / Hypocholesterolemic and anti-obesity effects of saponins from Platycodon grandiflorum in hamsters fed atherogenic diets / J. Food Sci 73:H195~H200
Chung JW / 2008 / Anti-inflammatory activity of prosapogenin methyl ester of platycodin D via nuclear factor-kappaB pathway inhibition / Biol. Pharm. Bull 31:2114~2120
Jang KJ / 2013 / Anti-inflammatory effects of saponins derived from the roots of Platycodon grandiflorus in lipopolysaccharidestimulated BV2 microglial cells / Int. J. Mol Med 31:1357~1366
Halliwell B / 2006 / Oxidative stress and neurodegeneration: where are we now? / J. Neurochem. 97:1634~1658
Park S / 2013 / The physiochemical characteristics and anti-oxidant activity of extracts of Platycodon grandiflorus (Jacquin) A. De Candolle / Planta Med. 79:1267~1268
Chung JW / 2008 / Anti-inflammatory activity of prosapogenin methyl ester of platycodin D via nuclear factor-kappaB pathway inhibition / Biol. Pharm. Bull 31:2114~2120
Jang KJ / 2013 / Anti-inflammatory effects of saponins derived from the roots of Platycodon grandiflorus in lipopolysaccharidestimulated BV2 microglial cells / Int. J. Mol Med 31:1357~1366
Halliwell B / 2006 / Oxidative stress and neurodegeneration: where are we now? / J. Neurochem. 97:1634~1658
Park S / 2013 / The physiochemical characteristics and anti-oxidant activity of extracts of Platycodon grandiflorus (Jacquin) A. De Candolle / Planta Med. 79:1267~1268
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