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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.11
- 수록면
- 569 - 579 (11page)
- DOI
- 10.7856/kjcls.2019.30.4.569
이용수
초록· 키워드
오류제보하기
This study explored the anti-inflammatory and antioxidant activity according to the flowers’ color and the flowers’ shape from in vitro cultured Platycodon grandiflorum (PG) adventitious root extract. The DPPH and ABTS radical scavenging activity showed that the increase was proportional to the extract’s concentration. As a result of measuring the DPPH and ABTS radical scavenging activity, it was confirmed that the component that enhanced antioxidation was contained in the PG adventitious root, and it was presumed that there was not a large change in the scavenging activity according to the flowers’ color and shape. The nitrite scavenging effect was the highest at pH 1.2 in all the tested samples. However, there was no distinct detection of nitrite scavenging effects of the pH range 6.0. After PG extract pretreatment at 50, 100, and 200 μg mL<SUP>-1</SUP>, the LPS-treated experimental group significantly inhibited NO production in a dose-dependent manner. The dose-response trends followed quadratic regressions in all the tested PG adventitious root extracts. The PG adventitious root extracts showed a considerable range of influence on cytokine secretion. The adventitious root extracts of PG against the production of inflammatory mediators TNF-α, IL-6 and IL-1β showed significant anti-inflammatory activity.
목차
ABSTRACT
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS AND DISCUSSION
Ⅳ. SUMMARY AND CONCLUSIONS
REFERENCES
참고문헌 (26)
참고문헌 신청
Frances Balkwill / 2005 / Smoldering and polarized inflammation in the initiation and promotion of malignant disease / Cancer Cell 7(3):211~217
Christian Bogdan / 2000 / Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity / Current Opinion in Immunology 12(1):64~76
부희옥 / 2012 / Assessment on Antioxidant Potential and Enzyme Activity of Some Economic Resource Plants / 한국자원식물학회지 25(3):349~356
W. Brand-Williams / 1995 / Use of a free radical method to evaluate antioxidant activity / LWT - Food Science and Technology 28(1):25~30
Chan MM / 2012 / In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties / Biochem Pharmacol 55:1955~1962
Christian Bogdan / 2000 / Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity / Current Opinion in Immunology 12(1):64~76
부희옥 / 2012 / Assessment on Antioxidant Potential and Enzyme Activity of Some Economic Resource Plants / 한국자원식물학회지 25(3):349~356
W. Brand-Williams / 1995 / Use of a free radical method to evaluate antioxidant activity / LWT - Food Science and Technology 28(1):25~30
Chan MM / 2012 / In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties / Biochem Pharmacol 55:1955~1962
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UCI(KEPA) : I410-ECN-0101-2020-590-000098690