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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제2호
- 발행연도
- 2020.1
- 수록면
- 178 - 186 (9page)
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초록· 키워드
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Licorice (Glycyrrhiza uralensis) contains several compounds that have been reported to alleviate menopausal symptoms via interacting with estrogen receptors (ERs). The compounds exist mainly in the form of glycosides, which exhibit low bioavailability and function. To bioconvert liquiritin and isoliquiritin, the major estrogenic compounds, to the corresponding deglycosylated liquiritigenin and isoliquiritigenin, respectively, licorice was fermented with Monascus, which has been demonstrated to deglycosylate other substances. The contents of liquiritigenin and isoliquiritigenin in Monascus-fermented licorice increased by 10.46-fold (from 38.03 μM to 379.75 μM) and 12.50-fold (from 5.53 μM to 69.14 μM), respectively, compared with their contents in non-fermented licorice. Monascus-fermented licorice exhibited 82.5% of the ERβ binding activity of that observed in the positive control (17 β-estradiol), whereas the non-fermented licorice exhibited 54.1% of the binding activity in an in vivo ER binding assay. The increase in the ERβ binding activity was associated with increases in liquiritigenin and isoliquiritigenin contents. Liquiritigenin acts as a selective ligand for ERβ, which alleviates menopausal symptoms with fewer side effects, such as heart disease and hypertension, compared with a ligand for ERα. In addition, Monascus-fermented licorice contained 731 mg/kg of monacolin K, one of the metabolites produced by Monascus that reduces serum cholesterol. Therefore, Monascus-fermented licorice is a promising material for the prevention and treatment of menopausal syndrome with fewer side effects.
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참고문헌 (45)
참고문헌 신청
Allred CD / 2001 / Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent(MCF-7)tumors in a dose-dependent manner / Cancer Res 61:5045~5050
Aura A-M / 2008 / Microbial metabolism of dietary phenolic compounds in the colon / Phytochem. Rev 7:407~429
Avis NE / 2001 / Is there a menopausal syndrome? Menopausal status and symptoms across racial/ethnic groups / Soc. Sci. Med 52:345~356
Blanc PJ / 1995 / Characterization of monascidin A from Monascus as citrinin / Int. J. Food Microbiol 27:201~213
Boonmuen N / 2016 / Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities / Steroids 105:42~49
Aura A-M / 2008 / Microbial metabolism of dietary phenolic compounds in the colon / Phytochem. Rev 7:407~429
Avis NE / 2001 / Is there a menopausal syndrome? Menopausal status and symptoms across racial/ethnic groups / Soc. Sci. Med 52:345~356
Blanc PJ / 1995 / Characterization of monascidin A from Monascus as citrinin / Int. J. Food Microbiol 27:201~213
Boonmuen N / 2016 / Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities / Steroids 105:42~49
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